Postoperative gastrointestinal dysfunction associated with abdominal hysterectomy particularly postoperative ileus, delayed bowel motility, abdominal distension, nausea/vomiting, and postoperative infections which may be influenced by inflammatory process. The study evaluates whether perioperative probiotic supplementation using Saccharomyces boulardii can improve bowel recovery and reduce postoperative complications. Probiotics, Saccharomyces boulardii, Hysterectomy, Postoperative recovery out
Conditions
Interventions
Bioflor 1 tab orally twice a day for 7 day before surgery,Standard treatment for preoperative, perioperative and postoperative
Experimental Dietary Supplement,No Intervention No treatment
Bioflor before surgery,Control
Sponsors
Rajavithi Hospital
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Participants diagnosed with benign gynecologic conditions requiring abdominal hysterectomy (open surgery) at Rajavithi Hospital, scheduled as elective procedures. 2.Participants aged 30-60 years. 3.Participants who are able to communicate Thai proficiently. 4.Participants who have a functional mobile phone for communication. 5.Participants who are willing to voluntarily participate in the study.
Exclusion criteria
Exclusion criteria: 1.Participants who have undergone more than one previous abdominal surgery. 2.Participants with immunocompromised conditions, such as HIV infection, poorly controlled diabetes mellitus (HbA1C > 8%), or autoimmune diseases requiring immunosuppressive therapy. 3.Participants with gastrointestinal disorders, including irritable bowel syndrome, chronic constipation, or chronic diarrhea. 4.Participants with known allergy to probiotics or any components of probiotic yeast formulations. 5.Participants with lactose intolerance. 6.Participants who consume less than 80% of the assigned probiotic doses (assessed through daily intake logs and pill counts upon hospital admission). 7.Participants who are pregnant or breastfeeding. 8.Participants who refuse to undergo the scheduled surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to normoactive bowel sounds during postoperative Hours, assessed by auscultation | — |
Secondary
| Measure | Time frame |
|---|---|
| time to first flatus, first defecation, first ambulation post operative Patient reported,length of hospital stay At hospital discharge Hour,surgical site infection 7 days, 2 weeks and 1 month, and 30-day Physical examination,Readmission rate 30-day Medical record | — |
Countries
Thailand
Contacts
Public ContactPinsuda Suwannarit
Rajavithi hospital
Outcome results
None listed