Persons who have high risk of developing HCC Early HCC detection, AFP, PIVKAII, AFP-L3, GALAD score,
Conditions
Interventions
Addition of AFP, PIVKA-II and AFP-L3 to standard of care which is Ultrasound ,Addition of HCC biomarkers to routing ultrasound for routine HCC screening in high-risk group
GALAD,Only Ultrasound
Sponsors
Ministry of Economy, Trade and Industry (METI)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients must be 18 years or older and be at high risk for HCC, defined as meeting at least one of the following criteria: 1. Cirrhosis from any cause. 2. Non-cirrhotic HBV, untreated, with a REACH-B score >8. 3. Non-cirrhotic HBV, on treatment, with a Modified PAGE-B score 9. 4. History of HCC in a first-degree relative.
Exclusion criteria
Exclusion criteria: 1.Previous diagnosis of HCC , diagnosis of any other malignancy (excluding basal cell carcinoma) 2. Current use of anticoagulant medication 3. Comorbidities associated with an expected survival of less than 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of hepatocellular carcinoma detection within 1 year of the study New hepatocellular carcinoma detected by imaging | — |
Secondary
| Measure | Time frame |
|---|---|
| Early case of HCC 6, 12 month Radiology (CT or MRI) | — |
Countries
Thailand
Contacts
Public ContactNaraporn Prayoonwiwat
Siriraj Hospital/Mahidol University
Outcome results
None listed