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Early Prediction of Fetal Growth Restriction Using Uterine Artery Doppler and NIPT in Thai Pregnant Women

Predictive Value of Uterine Artery Doppler and Cell-Free DNA Characteristics for Adverse Pregnancy Outcomes in Thai Pregnancies: An observational prospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20251125010
Enrollment
240
Registered
2025-11-25
Start date
2025-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal growth restriction Small for gestational age Preeclampsia Preterm birth Stillbirth Fetal Growth Retardation Small for Gestational Age Preeclampsia Preterm Birth Stillbirth Ultrasonography, Doppler Uterine Artery Cell-Free DNA Pregnancy Complications First Trimester of Pregnancy

Interventions

Pregnant women with a singleton pregnancy at 11 to 13 weeks 6 days undergoing routine Doppler and NIPT assessments
Other
Singleton pregnancies at 11 to 13 weeks 6 days

Sponsors

Faculty of Medicine, Chiang Mai University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age 20 years and above 2.Singleton pregnancy 3.Gestational age 11 to 13 weeks 6 days 4.Successful uterine artery Doppler assessment 5.Successful cell free DNA fetal fraction result from NIPT

Exclusion criteria

Exclusion criteria: 1. age less than 20 years 2. Multiple pregnancy 3. Major fetal anomaly detected on early ultrasound

Design outcomes

Primary

MeasureTime frame
Fetal growth restriction Delivery Estimated fetal weight or abdominal circumference below the third percentile, or below the tenth percentile with abnormal Doppler based on the Delphi consensus criteria

Secondary

MeasureTime frame
Small for gestational age Delivery Birth weight below the tenth percentile for gestational age with normal doppler,Preeclampsia Pregnancy or delivery Diagnosis documented in medical records based on standard clinical criteria,Preterm birth Delivery Delivery before 37 completed weeks of gestation,Stillbirth Delivery Fetal death confirmed in medical records

Countries

Thailand

Contacts

Public ContactThitapa Sermprasartkul

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University

thitapa.serm@cmu.ac.th0997017079

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026