Cutaneous Leischmaniasis cutaneous leishmaniasis platelet-rich plasma Glucantime ulcer healing antimony compounds wound therapy Pakistan
Conditions
Interventions
Standard sodium stibogluconate monotherapy at the dose of intramuscular 20mg/kg/day,Autologous platelet rich plasma derived gel dressing applied weekly in addition to standard Glucantime therapy
Glucantime ,Platelet rich plasma with Glucantime
Sponsors
Self funded
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult males and females 2. Age >14 years 3. At least one ulcerated Cutaneous Leischmaniasis lesion 4. Diagnosis confirmed by slit skin smear or biopsy
Exclusion criteria
Exclusion criteria: 1. Hemoglobin <10 g/dL 2. Platelet disorders 3. Abnormal baseline laboratory values 4. Diabetes mellitus 5. Severe hypovolemic conditions 6. Sepsis 7. Concurrent anti- inflammatory medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total number of Glucantime doses Till cure is achieved Frequency,duration of treatment Till cure is achieved Number of days,length of hospital stay Till cure is achieved Number of days | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety profile Weekly Liver function test, Serum amylase, Electrocardiogram, serum lipase, Renal function tests, Blood complete picture | — |
Countries
Pakistan
Contacts
Public ContactFatima Sajid
Riphah International University
Outcome results
None listed