Individuals in the pubertal period and post-pubertal period diagnosed with either, -Dental plaque-induced generalized gingivitis or, -Periodontal health Diagnosis made according to the criteria established in the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Chapple et al., 2018) Gingivitis Non-surgical periodontal therapy Puberty
Conditions
Interventions
This group will include individuals in the pubertal period with no clinical signs of periodontal inflammation (such as redness and/or edema in the gingiva), no radiographic bone loss, and no history o
Periodontally healthy group during puberty,Generalized gingivitis group during puberty,Periodontally healthy group post-puberty,Generalized gingivitis group post-puberty
Sponsors
Biruni University Scientific Research Projects
The Scientific and Technological Research Council of Turkiye
Eligibility
Sex/Gender
All
Age
8 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with periodontal health or dental plaque-induced generalized gingivitis according to the criteria established in the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Chapple et al., 2018) 2. Age between 8 and 30 years 3. For individuals 19 years and younger, having a body mass index (BMI) between the 5th and 85th percentile 4. For individuals 20 years and older, having a BMI between 18.5 and 24.9 kg/m2 5. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Presence of any systemic condition or disease that may affect periodontal tissues 2. Use of medications that may influence periodontal tissues or hormonal balance (such as antihypertensives, antidiabetics, oral contraceptives, or hormone supplements) 3. Pregnancy or breastfeeding 4. Smoking 5. Undergoing orthodontic treatment 6. Receiving periodontal treatment within the last 3 months 7. Use of systemic antibiotics within the last 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in IL-1 beta levels in gingival crevicular fluid at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) ELISA essay,Gingival inflammation at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) Gingival index,Changes in IL-1 beta levels in saliva at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) ELISA essay | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in IL-6 levels in gingival crevicular fluid and saliva at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) ELISA essay,Changes in the Prevotella intermedia levels at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) digital PCR,Probing depth at baseline (T0), 6 weeks after treatment (T1), and 12 weeks after treatment (T2) Periodontal probe (mm) | — |
Countries
Turkey
Contacts
Public ContactBurcu Karaduman
Biruni University, Faculty of Dentistry, Department of Periodontology
Outcome results
None listed