Patients who scheduled for elective laparoscopic cholecystectomy. laparoscopic cholecystectomy, postoperative pain control, nefopam, dexamethasone
Conditions
Interventions
- Dexamethasone 10 mg intravenous after induction
- Nefopam 20 mg in NSS 100 mL intravenous given 30 minutes before end of surgery
,- Dexamethasone 5 mg intravenous after induction
- Nefopam 20 mg i
Active Comparator Drug,Active Comparator Drug,No Intervention Drug
the high-dose dexamethasone combined with nefopam group (Group H),nefopam group (Group N),Control group(Group C)
Sponsors
Worapot Apinyachon
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18-70 years 2. Patients with an American Society of Anesthesiologists (ASA) physical status I-III 3. Patients scheduled for an elective laparoscopic cholecystectomy under general anaesthesia 4. Patients who have provided written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: 1. Patients with known allergies to any of the study drugs 2. Patients with underlying disease (E.g. liver failure, renal failure, Significant cardiovascular disease, history of convulsion, history of psychologic disorder or taking monoamine oxidase inhibitors, diabetes mellites) 3. Patients with a history of chronic opioid used 4. Patients with current use of steroids or immunosuppressive drugs 5. Morbidly obese patients (BMI more than 40 kg/m2) 6. Patients who are unable to understand or use the numeric pain rating scale or patient-controlled analgesia (PCA) pump
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric rating scale (NRS) pain scores at rest, and on exertion ranging from 0 (no pain) to 10 (worst imaginable pain), recorded at 0, 1, 6, 12 and 24 hours postoperatively 24hours after operation Nrs Score as 0-10 24hr Morphine comsump Record as volumn (Contineuous Data) | — |
Secondary
| Measure | Time frame |
|---|---|
| The 24-hour postoperative morphine consumption by IV PCA 24 hours postoperatively IV PCA morphine consumption (mg) in 24 hours postoperative,The incidence of post-operative nausea and vomitting 24 hours postoperatively Binary outcome as yes/no, rescue anti-emetic drug 24 hours postoperatively The name of drug and dose of anti-emetic drugs recr as volumn (mg),Incidence of hyperglycemia 24 hours postoperatively Binary outcome as yes/no | — |
Countries
Thailand
Contacts
Public ContactWorapot Apinyachon
Mahidol University
Outcome results
None listed