Growth retardation and complications in preterm infants, including retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) Potential benefits of massage therapy may incrased weight and altered body composition to increase IGF-1 levels, which may contribute to improved growth and reduced risk of ROP and BPD. coconut massage, Court-type Thai traditional massage, premature,Insulin-like growth factor I, retinopathy of prematurity, bronchopulmonary dysplasia, body composition, weight
Conditions
Interventions
1. Measure the infant'
s body temperature a until it reaches to 36.5 C or more before starting the intervention
2.Prepare the area by drawing opaque curtains before each procedure to prevent observation of the massage techn
s body temperature a until it reaches to 36.5 C or more before starting the intervention
2.Apply coconut oil at a dose of 4 ml/kg once daily without skin massage, continuously for 14 days ,no oil appl
Thai massage with coconut oil (TM+O),coconut oil only (O),standard care
Sponsors
Siriraj Hospital
Eligibility
Sex/Gender
All
Age
28 Weeks to 32 Weeks
Inclusion criteria
Inclusion criteria: 1.Infants with gestational age at birth between 28 and 32 weeks 2.Age greater than or equal to 14 days after birth, with a body weight at enrollment greater than or equal to 1,000 grams 3.Infants who have received enteral feeding (either orally or via oro-gastric tube) of at least 120 mL/kg/day
Exclusion criteria
Exclusion criteria: 1.Unstable vital signs, including: 1.1 Hypotension defined as mean arterial blood pressure below the 5th percentile for gestational age/postnatal age, requiring inotropic drugs or inhaled nitric oxide 1.2.Intubated with high respiratory support (FiO2 > 0.6 or mean airway pressure >16 cmH2O) 1.3 infants with lower respiratory support settings are eligible for the study 2.Severe congenital anomalies, including: 2.1 Severe lethal congenital anomalies such as anencephaly, trisomy 13, trisomy 18 2.2 Congenital heart disease except patent ductus arteriosus and atrial septal defect 2.3 Hydrops fetalis 3.Congenital skin abnormalities or skin infections, 3.1 Aplasia cutis with skin involvement >10% of body surface area 3.2 Abdominal wall defects such as omphalocele or gastroschisis 4.Gastrointestinal diseases requiring surgery or affecting bowel movement and nutrient absorption, including: 4.1 Congenital diaphragmatic hernia, hiatal hernia, tracheoesophageal fistula 4.2 Protein-losing enteropathy 4.3 Biliary atresia 4.4 Duodenal, jejunal, or ileal atresia; Hirschsprung disease 4.5 Surgical necrotizing enterocolitis (NEC) 4.6 Diagnosed short bowel syndrome or intestinal resection with risk of short bowel syndrome 5. Infants with implanted electronic devices, such as pacemakers 6. Infants at risk of bone fracture such as osteopenia of prematurity, osteogenesis Imperfecta 7. Maternal age < 18 years 8. Infants who may be involved in legal or medico-legal issues, for example cases in which there is an indication or suspicion that the pregnancy resulted from sexual assault
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| growth velocity day0,7,14 after intervention grams/day | — |
Secondary
| Measure | Time frame |
|---|---|
| growth velocity 0,7,14 days after intervention grams/kilograms/day,Anthropometric measurements 0,7,14 days after intervention centimeters,Serum Insulin-like Growth Factor-1 0,14 days after intervention ng/dL,incidence retinopathy of prematurity(ROP), bronchopulmonary Dysplasia (BPD) at discharge maximal severity,incidence of feeding intolerance 0,7,14 days after intervention percent,Length of hospital stay at discharge days,Adverse events during massage therapy during intervention period percent,incidence retinopathy of prematurity(ROP) and severity at discharge maximal severity,bronchopulmonary Dysplasia (BPD) and severity at discharge maximal severity | — |
Countries
Thailand
Contacts
Public ContactBuranee Yangthara
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University
Outcome results
None listed