Healthy participants Occupational Exposure Air Pollution Polycyclic Aromatic Hydrocarbons Particulate Matter Respiratory Tract Diseases Metabolic Syndrome Oxidative Stress Biomarkers
Conditions
Interventions
non-PAHs-exposed workers,PAHs-exposed grill workers
Screening,Screening
Control group,Exposed group
Sponsors
Thailand Science Research and Innovation
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Male, 20-50 years old and No smoking. 2.Exposed group: grill shop workers regularly exposed to grill smoke (n is 40). 3.Control group: workers not occupationally exposed to grill smoke (n is 20). 4.No acute infection or influenza-like illness at the time of assessment (e.g., high fever or symptoms suggesting active infection). 5.Willing and able to voluntarily participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe chronic diseases diagnosed by a physician, such as Cardiovascular disease, Renal failure, Significant active infection, Recent major surgery, Liver disease, gout, cancer, and Genetic diseases (e.g., thalassemia). 2. Conditions that may limit cooperation, such as, Psychosis, Drug addiction, and Alcoholism. 3. Refusal to participate or decision to withdraw at any time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Blood Glucose Single time point at enrollment Glucometer,Blood Biochemical Indicators (Liver Function Tests, Renal Function Tests, and Lipid profile) Single time point at enrollment Hematological test,2-hour postprandial glucose Single time point at enrollment Oral glucose tolerance test,Fasting Insulin Single time point at enrollment Enzyme-Linked Immunosorbent Assay (ELISA),HOMA-IR and HOMA-S Single time point at enrollment Calculation Formula,Malondialdehyde Single time point at enrollment Thiobarbituric acid reactive substances,hsCRP and IL-6 Single time point at enrollment Enzyme-Linked Immunosorbent Assay (ELISA),ICAM-1 and VCAM-1 Single time point at enrollment Enzyme-Linked Immunosorbent Assay (ELISA),red cell ROS and GSH Single time point at enrollment Assay kit,Metabolomics Single time point at enrollment Non-targeted proton nuclear magnetic resonance spectroscopy,urinary 8-OHdG, 1-OHP, and F2-isoprostanes Single time point at enrollment Gas chromatography-mass spectrometry,lung function testing Single time point at enrollment SpiroScout Spirometer,Urinary BPDE-DNA adducts Single time point at enrollment Assay kit | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Composition Single time point at enrollment Anthropometry,Blood Pressure Single time point at enrollment Blood pressure monitor,Exhaled carbon monoxide Single time point at enrollment Exhaled CO analyzer,oxygen saturation Single time point at enrollment finger pulse oximeter | — |
Countries
Thailand
Contacts
Public ContactSakaewan Ounjaijean
Chiang Mai University
Outcome results
None listed