Cardiometabolic diseases Insulin resistance Metabolic dysfunction Obesity and overweight Type 2 diabetes risk Elevated blood lipids Diet related metabolic response Prevention of non communicable diseases Human nutrition Low carbohydrate diet Dietary intervention Metabolic health Glucose metabolism Insulin sensitivity Energy expenditure Crossover randomised control trial
Conditions
Interventions
Participants will receive a full 24 hour meal package aligned with a typical Thai dietary pattern. The macronutrient distribution follows approximately 50 percent carbohydrate, 15 percent protein, and
Active Comparator Other,Experimental Other
Control diet,Low Carbohydrate Diet
Sponsors
Chulabhorn Royal Academy
University of Bath
Eligibility
Sex/Gender
All
Age
20 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Thai adults aged 20 to 64 years 2. Male or female 3.Body mass index between 18.5 and 34.9 kg per square meter 4.Generally healthy with no diagnosed metabolic or chronic diseases 5.Fasting blood glucose and lipid profile within normal clinical ranges 6.Willing and able to provide informed consent 7.Able to comply with dietary restrictions and all study procedures 8.Not currently following a special diet such as ketogenic or vegetarian 9.Able to attend all scheduled visits during the study period
Exclusion criteria
Exclusion criteria: 1.Diagnosis of diabetes cardiovascular disease or other metabolic disorders 2.Abnormal fasting blood glucose or lipid profile at screening 3.Abnormally high or low blood pressure considered unsafe by the research team 4.Use of medications that affect glucose or lipid metabolism 5.Smoking or use of tobacco products 6.Pregnant or breastfeeding 7.Known food allergies or intolerances that interfere with the study diets 8.History of disordered eating or significant weight change over 5 percent within the past three months 9.Engaged in competitive athletic training or extreme dietary practices 10.Diagnosis of gastrointestinal disorders or other conditions affecting nutrient metabolism 11.Participation in another clinical trial within the previous three months 12.Inability to follow dietary instructions or comply with study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile Baseline before meal consumption and 24 hours after completion of each dietary intervention session Venous blood sampling and biochemical analysis of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol using standard clinical chemistry assays in a certified laboratory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose level Baseline and after at least 10 hours of fasting at the end of each dietary intervention session enous blood sampling and measurement of fasting plasma glucose using standard biochemical assays,Resting metabolic rate Baseline before each dietary intervention session Indirect calorimetry performed in a quiet controlled room under fasting resting conditions,Anthropometric measurements and body composition Baseline and 24 hours after each dietary intervention session Body weight height waist circumference abdominal height and bioimpedance scale assessment using standardized measurement protocols | — |
Countries
Thailand
Contacts
Public ContactJariya Buniam
Chulabhorn Royal Academy, Thailand
Outcome results
None listed