Thai elderly Nonvalvular atrial fibrillation Apixaban plasma concentration Thai elderly, nonvalvular atrial fibrillation, Real world, Apixaban plasma level
Conditions
Interventions
Thai patients aged 65 years or older with nonvalvular atrial fibrillation receiving apixaban. Plasma trough and peak apixaban concentrations be measured
Treatment
Apixaban plasma level in elderly
Sponsors
Silpakorn University, Thailand
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Thai patients aged 65 years or older 2. Diagnosed with nonvalvular atrial fibrillation (NVAF) and receiving apixaban therapy for at least seven consecutive days. 3.Agree to participate in apixaban adherence evaluation 4.Patients who agree to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Presence of moderate to severe mitral stenosis or mechanical prosthetic heart valve. 2. Patients with psychiatric disorders or dementia without caregiver supervision for medication adherence. 3. Patients unwilling or unable to maintain intravenous access for 3 hours or to undergo two blood samplings as required by the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apixaban plasma concentration at least 7 days after treatment with apixaban Chromogenic Anti-Xa assay | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between apixaban plasma concentration and bleeding/thrombosis events 1 year after apixaban plasma concentration measured Relationship : logistic regression, Clinical outcomes: definite diagnosis by physicians,Factor associated apixaban plasma concentration date at apixaban plasma concentration measured simple linear regression with Pearson correlation coefficient | — |
Countries
Thailand
Contacts
Public ContactPiyachat Saringkarn
Phramongkutklao hospital
Outcome results
None listed