Effects of watercress on risk of cardiovascular diseases

Effects of watercress consumption on biomarkers related to risk of cardiovascular diseases in Thai adults, Chiang Mai, Thailand

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251119004

Enrollment

Registered

2025-11-19

Start date

2025-01-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low or moderate risk of cardiovascular diseases middle-aged adults Cardiovascular diseases Vegetables Antioxidant Oxidative stress Biomarkers Adult Thailand Proteomics Metabolomics

Interventions

Participants will receive the dried watercress packed in 500 mg capsules. They will consume 4 capsules after every meal and before going to bed (4 times per day). According to this amount of watercres

Experimental Dietary Supplement,Placebo Comparator No treatment

Watercress treatment,Placebo treatment

Eligibility

Sex/Gender

All

Age

40 Years to 59 Years

Inclusion criteria

Inclusion criteria: 1. Have less than 15% of CVD risk, according to the Framingham Risk Equation. 2. Have at least one of the following conditions: systolic blood pressure of 130-160 mmHg, total cholesterol of 200-240 mg/dL, fasting blood glucose of 100-125 mg/dL, BMI greater than 25, or waist circumference greater than 90 cm for males or greater than 80 cm for females.

Exclusion criteria

Exclusion criteria: 1. Presence of chronic diseases. 2. BMI greater than 40. 3. Current or recent (within the previous 6 months) significant weight loss or gain (more than 6% of body weight) or actively trying to lose weight. 4. Use of BP-lowering, blood glucose-lowering, or cholesterol-lowering medication. 5. Pregnant or breastfeeding women. 6. People with psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
Cardiovascular and vascular health At baseline and post-intervention Blood pressure, cardio-ankle vascular index (CAVI), and ankle-brachial index (ABI),Metabolic and lipid markers At baseline and post-intervention Fasting blood glucose (FBG) and lipid profiles (TC, TG, HDL-C, LDL-C),Inflammation and oxidative stress At baseline and post-intervention Oxidized LDL, C-reactive protein (CRP), glutathione (GSH), and total antioxidant capacity (TAC)	—

Measure

Time frame

Cardiovascular and vascular health At baseline and post-intervention Blood pressure, cardio-ankle vascular index (CAVI), and ankle-brachial index (ABI),Metabolic and lipid markers At baseline and post-intervention Fasting blood glucose (FBG) and lipid profiles (TC, TG, HDL-C, LDL-C),Inflammation and oxidative stress At baseline and post-intervention Oxidized LDL, C-reactive protein (CRP), glutathione (GSH), and total antioxidant capacity (TAC)

—

Secondary

Measure	Time frame
Physical and anthropometric data At baseline and post-intervention Weight, height, waist and hip circumferences, and body composition (BIA)	—

Countries

Thailand

Contacts

Public ContactKanokwan Kulprachakarn

Research Institute for Health Sciences (RIHES), Chiang Mai University

kanokwan.kul@cmu.ac.th053936148

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026