Permanent Post-stroke non-fluent aphasia Post-stroke non-fluent aphasia Donepezil Thai adaptation of Western Aphasia Battery
Conditions
Interventions
Taking donepezil 2.5 mg for 4 weeks then then increasing the dosage to 5 mg for the subsequent 12 weeks,Taking placebo for 16 weeks (placebo will be adjusted to look similar to the intervention group
Experimental Drug,Placebo Comparator Drug
Donepezil,Placebo
Sponsors
Ratchadapiseksomphot Research Funds Type II
Grants for development of new faculty staff, Ratchadaphiseksomphot fund, Chulalongkorn University,Berlin Pharmaceutical Industry Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Non-fluent aphasia due to ischemic stroke for more than 1 year despite speech rehabilitation program, confirm by Thai adaptation of Western Aphasia Battery
Exclusion criteria
Exclusion criteria: 1. Severe language comprehension difficulties, 2. Speech problems not due to language disorders such as severe spastic dysarthria, akinetic mutism or severe depression, 3. Currently receiving treatment with acetylcholinesterase inhibitor, 4. Precautions for donepezil administration such as bradycardia, hypotension, seizure, etc., 5. Unable to perform brain MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of aphasia Before and after the intervention Scores and subscores of the Thai adaptation of Western Aphasia Battery | — |
Secondary
| Measure | Time frame |
|---|---|
| Communication abilities Before and after the intervention Communicative Activity Log,Brain structure and connectivity Before and after the intervention Brain MRI (T1, T2-FLAIR, DTI, resting state fMRI),Side effect Along the intervention period Questionaire | — |
Countries
Thailand
Contacts
Public ContactThachamai Smitasiri
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed