Patients with symptomatic knee osteoarthritis at Kellgren &
Conditions
Interventions
Treatment,Treatment
Adipocyte-derived mesenchymal stem cells (ADSCs),hyaluronic acid (HA)
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with knee osteoarthritis who received ADSC and HA treatment in 2022 as part of the investigator's project. 2. Patients aged between 40 and 70 years. 3. Patients with knee osteoarthritis classified as Kellgren -Lawrence grade 1-2. 4. Patients who discontinued the use of NSAIDs for at least 2 weeks. 5. Patients who voluntarily agreed to participate in the research and signed the informed consent form after receiving a full explanation of the study details.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary osteoarthritis. 2. Patients with a history of significant trauma, such as fractures of the knee and malformation of the bones. 3. Patients with cancer. 4. Patients with swollen, red, or hot knees. 5. Patients experiencing worsening pain or side effects from the procedure. 6.Patients with diabetes (DM), immunocompromised conditions. 7. Patients who have previously received stem cell therapy. 8. Patients with abnormal blood clotting or taking anticoagulant medications. 9. Pregnant women and breastfeeding mothers. Please note that this revision clarifies the criteria for selecting and excluding participants in the randomized controlled trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| radiographic improvement 36 months MRI ultrasound | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical improvement 36 months WOMAC | — |
Countries
Thailand
Contacts
Public ContactPonthep tangkanjanavelukul
University
Outcome results
None listed