Comparison of Wound-Related Outcomes Between Topical Tissue Adhesive and Subcuticular Suture for Skin Closure in Minimally Invasive Spine Surgery

Comparison of Wound-Related Outcomes Between Topical Tissue Adhesive and Subcuticular Suture for Skin Closure in Minimally Invasive Spine Surgery: A Randomized Controlled Trial in the Same Patient

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251028004

Enrollment

Registered

2025-10-28

Start date

2023-10-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative wound healing and closure outcomes in patients undergoing minimally invasive spinal surgery. Topical tissue adhesive

Interventions

Skin closure using 2-octyl cyanoacrylate tissue adhesive applied to approximated skin edges following minimally invasive spine surgery. The adhesive was allowed to polymerize and form a waterproof fil

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Topical tissue adhesive,Subcuticular suturing

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients who underwent minimally invasive spinal surgery (MISS) via a parallel paramedian incision

Exclusion criteria

Exclusion criteria: 1. History of spinal surgery 2. History of spinal infection 3. Scars near the planned incision site 4. Suspected local infection or dermatologic disease over the surgical field 5. Known allergy to cyanoacrylate.

Design outcomes

Primary

Measure	Time frame
Cosmetic (scar-assessment) 2 weeks, 6 weeks, and 12 weeks the Patient and Observer Scar Assessment Scale (POSAS) and the Vancouver Scar Scale (VSS),Cosmetic (scar-assessment) 12 months Antera 3D	—

Secondary

Measure	Time frame
Incision length Admission Measured using a standard ruler,Wound-closure time Intra-operative Stopwatch from the start to completion of skin closure,Number of dressing changes Before discharge Recorded from postoperative nursing records,Patient satisfaction 2 weeks, 6 weeks, and 12 weeks 100-point visual analog scale (VAS),Wound-related complications at 2 weeks, 6 weeks, and 12 weeks Assessed by clinical evaluation during postoperative follow-up visits	—

Measure

Time frame

Incision length Admission Measured using a standard ruler,Wound-closure time Intra-operative Stopwatch from the start to completion of skin closure,Number of dressing changes Before discharge Recorded from postoperative nursing records,Patient satisfaction 2 weeks, 6 weeks, and 12 weeks 100-point visual analog scale (VAS),Wound-related complications at 2 weeks, 6 weeks, and 12 weeks Assessed by clinical evaluation during postoperative follow-up visits

—

Countries

Thailand

Contacts

Public ContactParin Samapath

Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University

Palm-@live.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026