The effect of positive end expiratory pressure (PEEP) to oxygenation after weaning of cardiopulmonary bypass in coronary artery bypass graft surgery ( CABG)

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251026002

Enrollment

Registered

2025-10-26

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient who undergoing coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass CABG PEEP oxygenation Cardiopulmonary bypass

Interventions

using volume control ventilation (VCV) with fraction of inspired oxygen (FIO2) of 0.5 in air , Tidal volume (TV) 6-8 ml/kg ( predicted BW) , Respiratory rate (RR) 10-20 breaths/min , Keep PaCO2

Active Comparator Device,No Intervention Device

PEEP ,ZEEP

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) Patient who undergoing coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass 2)ASA II-IV

Exclusion criteria

Exclusion criteria: 1) Patient denied 2) Chronic obstructive pulmonary disease 3) Restrictive pulmonary disease 4) Emergency surgery 5) Hemodynamic instability 6) Patients who remained in the invasive mechanical ventilator 7) Preoperative left ventricular ejection fraction < 40 % 8) Hemoglobin < 10 g/dL 9) obesity ( BMI > 35 kg/m2) 10) Active smoking ( cigarette cessation < 8 wk) 11) Valvular heart disease

Design outcomes

Primary

Measure	Time frame
oxygenation End of surgery ( when start skin closure) PaO2 measured from arterial blood gas at the time of skin closure	—

Secondary

Measure	Time frame
Oxygenation at baseline PaO2 from arterial blood gas,Oxygenation after protamine 10 min PaO2 from arterial blood gas,Oxygenation Immediate post-operation at ICU PaO2 from arterial blood gas,Cardiovascular complication intraoperative intraoperative record if have cardiovascular complication intraoperative ,Duration of ICU stay postoperative at ICU record ,Duration of mechanical ventilation postoperative at ICU record	—

Measure

Time frame

Oxygenation at baseline PaO2 from arterial blood gas,Oxygenation after protamine 10 min PaO2 from arterial blood gas,Oxygenation Immediate post-operation at ICU PaO2 from arterial blood gas,Cardiovascular complication intraoperative intraoperative record if have cardiovascular complication intraoperative ,Duration of ICU stay postoperative at ICU record ,Duration of mechanical ventilation postoperative at ICU record

—

Countries

Thailand

Contacts

Public ContactPunnika Yanyangkul

Faculty of Medicine, Khon Kaen University

best.njr@gmail.com0899447031

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026