Efficacy of Positive Online Mental Imagery-based Therapy on Severity of Depression and Rate of Adaptive Behaviour in Major Depressive Disorder

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251025001

Enrollment

Registered

2025-10-25

Start date

2022-06-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder (MDD) characterized by persistent low mood, loss of interest or pleasure (anhedonia), and associated symptoms such as fatigue, cognitive impairments, and maladaptive behaviors. The study focuses on assessing the efficacy of online mental imagery-based therapy in reducing depressive symptom severity and improving adaptive behavioral outcomes in individuals diagnosed with MDD. major depressive disorder, behavioral activation, functional behavior, and positive mental imag

Interventions

This arm involves a 4 week online positive mental imagery intervention for individuals with major depressive disorder. Participants receive weekly 45 minute therapist guided sessions and daily 15 to 2

Experimental Behavioral,Sham Comparator Behavioral

Online Positive Mental Imagery-Based Therapy (OPMIBT),Online Neutral Imagery Training (Control Condition)

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Adult outpatients aged 18-50 years with DSM-5 confirmed Major Depressive Disorder MDD 2. Diagnosis via semi-structured clinical interview by psychiatrist at Zareh Hospital Clinic Sari 3. Written informed consent 4. Ability to use online intervention platform 5. No severe cognitive or sensory impairments

Exclusion criteria

Exclusion criteria: Exclusion criteria comprised: (1) voluntary withdrawal from the study at any stage per participant request, (2) non-adherence to the intervention protocol (incomplete sessions or failure to perform assigned exercises), (3) severe medical or psychiatric comorbidities (e.g., psychosis, substance use disorders) that could interfere with treatment outcomes (though not explicitly stated, such exclusions are standard in clinical trials), and (4) concurrent participation in other psychotherapeutic interventions that might confound study results. These criteria were implemented to maintain protocol integrity and ensure valid assessment of the experimental intervention's effects.

Design outcomes

Primary

Measure	Time frame
Change in Depression Severity At 4 weeks post-intervention initiation Hamilton depression test,Dimensional Anhedonia Rating Scale (DARS),Spontaneous Use of Mental Imagery Scale (SUIS)	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Iran

Contacts

Public ContactYazdan Naderi Rajeh

Mazandaran University of Medical Sciences, Iran

yazdan.nr66@yahoo.com989118230034

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026