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Relationship between End-Expiratory Lung Impedance changes, Cardiac output and Fluid responsiveness status during Passive Leg Raising Test in Medical Intensive Care Unit.

Relationship between End-Expiratory Lung Impedance changes, Cardiac output and Fluid responsiveness status during Passive Leg Raising Test in Medical Intensive Care Unit.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20251023002
Enrollment
100
Registered
2025-10-23
Start date
2024-10-02
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanically ventilated patients, Newly-admission Intensive Care patients, Respiratory Failure, Shock Electrical Impedance Tomography

Interventions

Cardiac Output Increases more than 10% via Internally-calibrated pulse contour analysis,Cardiac Output Increases less than 10% via Internally-calibrated pulse contour analysis
Basic Science,Basic Science

Sponsors

Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. patients aged equal or more than 18 years 2. admitted to the MICU 3. intubated with end-tidal CO2 (EtCO2) monitoring 3. equipped with an arterial line for CO monitoring, and with available global EELi measurements using an EIT device. 4. Informed consent was obtained from each patient or their legal surrogate.

Exclusion criteria

Exclusion criteria: 1. contraindications to the PLR test (e.g., limb amputation, deep vein thrombosis, or elevated intra-abdominal pressure) 2. a history of pulmonary embolism 3. morbid obesity (BMI > 35) 4. and active pregnancy.

Design outcomes

Primary

MeasureTime frame
Correlation between End Expiratory Lung impedance and Cardiac Output, Fluid responsiveness status 0 minutes, 2minutes during Passive leg raising test protocol, 1minute and 5 minute after Passive leg raising test protocol Electrical Impedance Tomography machine, Internally-calibrated pulse contour analysis

Secondary

MeasureTime frame
Correlation between End Expiratory Lung impedance and End tidal Carbondioxide, Fluid responsiveness status 0 minutes, 2minutes during Passive leg raising test protocol, 1minute and 5 minute after Passive leg raising test protocol Electrical Impedance Tomography machine, End-tidal Carbondioxide monitoring

Countries

Thailand

Contacts

Public ContactWitsawat Wisupakarn

Critical Care Fellowship

witsawat90@gmail.com076361234

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026