Pediatric oncology patients under Chemotherapy session Chemotherapy, Glutamine, Biomarker, Oral mucositis, Children
Conditions
Interventions
Dosage
Body weight under 30 kg : 0.65 gm/kg/day
Body weight above 30 kg : 15 gram per oral 2 times/day (adult dose)
Continue for 14 days during Chemotherapy session,Dosage
Body weight under 30 kg :
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
L-Glutamine powder (BioKyowa Inc., CAS No. 56-85-9),Dextrin (King Chulalongkorn memorial hospital)
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age 1-18 year old 2. Pediatric oncology patients under Chemotherapy session at King Chulalongkorn Memorial hospital, Thai Red Cross society 3. Receiving the same chemotherapy regimen, dosage and duration on two separate occasions, with at least a one-week interval between courses. 4. Receiving chemotherapy that includes at least one of this following: Methotrexate, Doxorubicin, Cyclophosphamide, Cisplatin or Cytarabine
Exclusion criteria
Exclusion criteria: 1. Patients with cancer who have received chemotherapy for the first time (induction phase of treatment) 2. Patients with cancer that has spread to the oral tissues or with abnormal cancer types in the oral cavity. 3. Experiencing inflammation or infection in the oral tissues before participating in the research study for 1 week 4. Unable to consume any other products besides cancer treatment drugs due to the severity of the cancer or complications 5. Receiving treatment in the intensive care unit or being treated with inotrope 6. Consuming food or nutritional supplements that have been studied and found to affect the treatment of oral inflammation, which may include: Medical nutritional supplements (Oral Nutritional Supplement) or Total Parenteral Nutrition containing Glutamine, honey, Vitamins A, B, C, D, and E, Hyaluronic acid, Triamcinolone, Licorice root (Glycyrrhiza glabra), Zinc, or history of allergy to Glutamine components
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6 2 weeks Electrochemiluminescence Immunoassay (ECLIA),C-reactive protein 2 weeks Turbidimetric Immunoassay,Antioxidant GSH 2 weeks High Performance Liquid Chromatography (HPLC),TNF alpha 2 weeks Enzyme-Linked Immunosorbent Assay (ELISA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Mucositis 2 weeks World Health Organization Oral Mucositis Grading Scale | — |
Countries
Thailand
Contacts
Public ContactBuabongkoj Punnanan
King Chulalongkorn Memorial Hospital
Outcome results
None listed