Effect of Glycerin Enema versus NSS Irrigation on Enteral Feeding in Preterm Infants: A Randomized Controlled Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251020006

Enrollment

Registered

2025-10-20

Start date

2025-03-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To compare time to full enteral feeding using glycerin enema and NSS irrigation in preterm infants Glycerin, NSS irrigation, full enteral feeding

Interventions

GE group, once daily glycerin enema will be performed using 1 mL/kg of diluted glycerine (1:4),NSS group, once daily rectal irrigation will be performed using 10-20 mL/kg of NSS

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Glycerin Enema,NSS Irrrigation

Eligibility

Sex/Gender

All

Age

1 Days to 3 Days

Inclusion criteria

Inclusion criteria: 1. Preterm infants with GA 25 0/7 -32 6/7 admitted to NICUs or special care nursery (SCN) 2. Hemodynamically stable within their first 72 hours

Exclusion criteria

Exclusion criteria: 1. Passed transitional or normal stool 2. Known chromosome abnormalities 3. Major congenital anomalies such as GI malformation (abdominal wall defects, TE fistula, anorectal malformation, congenital diaphragmatic hernia) 4. Cyanotic congenital heart diseases

Design outcomes

Primary

Measure	Time frame
Time to full enteral feeding 120 ml/kg/day Time to full enteral feeding Day	—

Secondary

Measure	Time frame
Time to complete pass meconium Time to complete pass meconium Day	—

Countries

Thailand

Contacts

Public ContactAnchalee Limrungsikul

Mahidol university

anchalee.lim@mahidol.ac.th0818032892

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026