Patients with facial acne scar. acne scar, mannitol, sterile water
Conditions
Interventions
Patients were injected using electromagnetic-based transdermal delivery with Mannitol at acne scar for 3 session, one month apart. Then they were instructed to follow up at 1, 3 and 6 months after com
Active Comparator Drug,Active Comparator Drug
Electromagnetic-based transdermal delivery of Mannitol,Electromagnetic-based transdermal delivery of sterile water
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 20 and 60 years, of any gender. 2. Patients with moderate or greater facial atrophic acne scars, as assessed by the Qualitative Global Scarring Grading System. 3. Patients who voluntarily consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or breastfeeding. 2. Patients with a history of collagen-related disorders, such as Cushing's syndrome or Ehlers-Danlos syndrome. 3. Patients with facial dermatitis, wounds, or active skin infections. 4. Patients who have cancer, are currently undergoing cancer treatment, or have skin cancer in the treatment area. 5. Patients with a history of immunodeficiency, including those infected with HIV or diagnosed with AIDS. 6. Patients with a history of abnormal photosensitivity. 7. Patients who have received facial treatments such as dermal fillers, botulinum toxin, collagen biostimulators, platelet-rich plasma (PRP), or thread lifting within 6 months prior to study participation. 8. Patients who have undergone laser treatment for facial acne scars within 6 months prior to study participation. 9. Patients with a history of keloid scars or skin lesions in the treatment area. 10. Patients who have used vitamin A or its derivatives within 6 months prior to study participation. 11. Patients with a history of psychiatric disorders, as assessed by a qualified physician. 12. Patients who do not consent to photographic documentation for treatment evaluation. 13. Patients with a history of allergy to local anesthetics. 14. Patients with a pacemaker or any implanted electrical device that may be affected by electromagnetic equipment. 15. Patients with a bleeding disorder or those currently taking anticoagulant medication. 16. Patients who are taking systemic corticosteroids or using topical steroid cream in the treatment area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne scar depression volume analysis Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Antera 3D,Texture improvement Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Antera 3D,Goodman and Baron's Quantitative Global Acne Scarring Grading System Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Goodman and Baron's Quantitative Global Acne Scarring Grading System | — |
Secondary
| Measure | Time frame |
|---|---|
| Melanin and erythema index Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. mexameter,Physician improvement scale Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Quartile scale,Patient improvement scale Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Quartile scale,Pain score immediate Visual analog scale,Safety Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment, 3 and 6 months after complete the treatment. Adverse event | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed