Postprandial Hyperglycemia Prediabetes Type 2 Diabetes Mellitus precision nutrition postprandial glucose gut microbiota artificial intelligence Thai food
Conditions
Interventions
The intervention is an 14-day personalized nutrition program. Upon enrollment, all 200 participants will undergo a baseline assessment that includes a review of their medical and dietary history, phys
Experimental Other
Sponsors
Program Management Unit for Competitiveness (PMUC)
Modish Food Design Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-80 years. 2. Body Mass Index (BMI) greater than 18.5 kg/m2. 3. Participants may have normal blood glucose, prediabetes (fasting plasma glucose 100-125 mg/dL or HbA1c 5.7-6.5 percent), or type 2 diabetes treated with lifestyle modification, metformin, and or pioglitazone with an HbA1c level less than or equal to 9 percent. 4. If on medication for hypertension, diabetes (metformin), or hyperlipidemia, the dosage must be stable for at least 3 months prior to enrollment. 5. Must own a smartphone capable of installing the necessary application for the continuous glucose monitoring (CGM) system.
Exclusion criteria
Exclusion criteria: 1.History of allergy to food or components in the study products. 2.Significant weight change (greater than 5 kg) within 6 weeks before the study. 3.Severe uncontrolled hypertension (greater than or equal to 180 over 110 mmHg) or hypertriglyceridemia (greater than 500 mg per dL). 4.HbA1c greater than 9 percent or fasting plasma glucose greater than 200 mg per dL. 5.Use of steroids or antibiotics within 6 weeks before the study. 6.Pregnant or lactating. History of diseases affecting digestion and absorption (e.g., short bowel syndrome, inflammatory bowel disease, chronic pancreatitis). 7.Previous bariatric surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Postprandial Glycemic Response. over 14-day period of dietary intervention Glucose levels measured via a continuous glucose monitoring (CGM) device every 5 minutes for 14 days. Analysis will include standard metrics such as Area Under the Curve (AUC). | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota composition Baseline Analysis of stool samples using 16S rRNA sequencing to determine the relative abundance of microbial genera.,Metabolic markers Baseline Blood tests including fasting plasma glucose, fasting insulin, HbA1c, and lipid profile (total cholesterol, triglycerides, HDL and LDL cholesterol). | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed