The Renal Protective Effect of Intravenous Amino Acids in Patients Undergoing Unilateral Nephrectomy : A Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251014005

Enrollment

100

Registered

2025-10-14

Start date

2025-11-28

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative acute kidney injury after unilateral nephrectomy intravenous amino acid, postoperative acute kidney injury (AKI), renal functional reserve (RFR), urine neutrophil gelatinase-associated lipocalin (uNGAL), creatinine clearance (CrCl), glomerular filtration rate (GFR), unilateral nephrectomy

Interventions

7.2% amino acid (KIDMIN) 500 ml IV drip rate 150 ml/hr intraoperative since anesthetic induction.,Ringer&#039

s acetate solution 500 ml iv drip rate 150 ml/hr as placebo

Experimental Drug,Placebo Comparator No treatment

Intravenous amino acid (7.2% KIDMIN),Ringer&#039

s acetate solution

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age 18 year or more 2. Undergoing unilateral nephrectomy 3. American Society of Anesthesiologists (ASA) class 1-3

Exclusion criteria

Exclusion criteria: 1. Bilateral nephrectomy 2. Pregnancy 3. History of drug allergy or amino acid involved in the study 4. Baseline estimated GFR (eGFR) < 45 ml/min/1.73m2 5. Abnormal amino acid metabolism 6. Advanced impair hepatic function 7. Severe metabolic acidosis 8. Congestive heart failure 9. Fluid overload

Design outcomes

Primary

Measure	Time frame
postoperative acute kidney injury (AKI) 7 days postoperative period serum creatinine in postoperative (POD) at day 1, 3, 7 and urine output	—

Secondary

Measure	Time frame
severity of AKI 7 days postoperative period serum creatinine ,recruitment of renal functional reserve (RFR) 24 hours postoperative period calculate RFR from creatinine clearance,urine neutrophil gelatinase-associated lipocalin (uNGAL) at 6 and 24 hour after surgery spot urine at 6 and 24 hour after surgery,creatinine clearance 24 hours postoperative period collect urine 24 hours postoperative period,glomerular filtration rate (GFR) POD 1 and 3 1st and 3rd day after surgery collect blood sample at 1st and 3rd day after surgery,urine output 24 hours postoperative 24 hours postoperative period monitor urine output ,serum creatinine POD 1 and 3 1st and 3rd day after surgery collect blood sample at 1st and 3rd day after surgery	—

Measure

Time frame

severity of AKI 7 days postoperative period serum creatinine ,recruitment of renal functional reserve (RFR) 24 hours postoperative period calculate RFR from creatinine clearance,urine neutrophil gelatinase-associated lipocalin (uNGAL) at 6 and 24 hour after surgery spot urine at 6 and 24 hour after surgery,creatinine clearance 24 hours postoperative period collect urine 24 hours postoperative period,glomerular filtration rate (GFR) POD 1 and 3 1st and 3rd day after surgery collect blood sample at 1st and 3rd day after surgery,urine output 24 hours postoperative 24 hours postoperative period monitor urine output ,serum creatinine POD 1 and 3 1st and 3rd day after surgery collect blood sample at 1st and 3rd day after surgery

—

Countries

Thailand

Contacts

Public ContactChitsanuphong Rungpaiboonrit

King Chulalongkorn Memorial Hospital

chitsanuphong_r@hotmail.com0866783735

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026