EFFICACY OF INTRAVENOUS FLUID REHYDRATION THERAPY WITH NORMAL SALINE SOLUTION COMPARED TO RINGER'S LACTATE SOLUTION IN CHILDREN WITH ACUTE DIARRHEA: A RANDOMIZED CONTROLLED TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251007010

Enrollment

Registered

2025-10-07

Start date

2023-07-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute diarrhea with dehydration Acute diarrhea, Children, Fluid therapy, Dehydration, Bicarbonate

Interventions

Participants received Ringer&#039

s lactate solution at a rate of 10 milliliters per kilogram per hour for a duration of 2 hours. Data on clinical symptoms and blood chemistry were collected before and after treatment,Participants rec

Experimental Drug,Experimental Drug

Ringer&#039

s lactate solution,Normal saline solution

Eligibility

Sex/Gender

All

Age

1 Months to 15 Years

Inclusion criteria

Inclusion criteria: 1. Children diagnosed with acute diarrhea with dehydration, who received treatment at Princess Maha Chakri Sirindhorn Medical Center in Nakhon Nayok province from July 2023 to July 2024

Exclusion criteria

Exclusion criteria: 1. Chronic illness, 2. Respiratory failure or ARDS, 3. Hypotension, shock, 4. Surgical condition, 5. Sepsis

Design outcomes

Primary

Measure	Time frame
Serum bicarbonate level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine	—

Secondary

Measure	Time frame
Serum sodium level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum potassium level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum chloride level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum blood urea nitrogen before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum creatinine level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Body temperature before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Axillary thermometer,Pulse rate before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Pulse oximeter	—

Measure

Time frame

Serum sodium level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum potassium level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum chloride level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum blood urea nitrogen before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Serum creatinine level before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Collected blood of participants both groups (Ringer's lactate group and Normal saline group) by Healthcare professionals then interpreted results by the automation machine ,Body temperature before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Axillary thermometer,Pulse rate before treatment (on admission), after treatment (at 2 hours after received intravenous fluid) Pulse oximeter

—

Countries

Thailand

Contacts

Public ContactSanguansak Rerksuppaphol

Srinakharinwirot University

sanguansak_r@hotmail.com037395451

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026

EFFICACY OF INTRAVENOUS FLUID REHYDRATION THERAPY WITH NORMAL SALINE SOLUTION COMPARED TO RINGER&#039;S LACTATE SOLUTION IN CHILDREN WITH ACUTE DIARRHEA: A RANDOMIZED CONTROLLED TRIAL