Carpal Tunnel Syndrome (CTS) Neuropathic Pain Numbness Peripheral Neuropathy Carpal Tunnel Syndrome (CTS) Vitamin D supplementation Functional score Pan score
Conditions
Interventions
Participants in the intervention group will receive oral cholecalciferol vitamin D3 at a dose of 20000 IU once weekly for 12 weeks. The capsules will be taken once per week in the morning before meals
Experimental Drug,Placebo Comparator Drug
Cholecalciferol (Vitamin D),Control Placebo
Sponsors
The study is sponsored by the Office of the Science Research and Innovation Promotion (SRIP) under the Fundamental Fund (FF) program of the Thailand Science Research and Innovation (TSRI), formerly known as NRCT, Fiscal Year 68. The FF program supports basic research aligned with national research and innovation strategies and is administered through block grants to universities and research institutes.
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1 Age between 18 and 75 years. 2 Diagnosed with Carpal Tunnel Syndrome (CTS) based on patient history (symptoms of pain, numbness, or tingling along the median nerve distribution of the hand) and physical examination (positive Tinel sign, positive modified Phalen test, or positive Durkan compression test). 3 Patients with blood vitamin D levels that are either low or within the normal range. 4 Nerve conduction velocity test indicating mild or moderate degree of CTS. The diagnostic criteria for CTS severity are: Mild degree: Distal sensory latency (DSL) between 2.8 to 3.2 ms plus a positive Bactrian test, or DSL > 3.2 ms. Moderate degree: Distal motor latency (DML) > 4.2 ms. 5 Able to provide written informed consent. If unable to sign, other methods such as fingerprinting can be used, provided the participant consents to participate in the study.
Exclusion criteria
Exclusion criteria: 1. History of hand injury or prior hand/wrist surgery. 2. Presence of secondary causes of carpal tunnel syndrome (CTS), including diabetes mellitus, pregnancy, hypothyroidism, inflammatory arthropathy, chronic kidney disease, cerebrovascular disease, malabsorption syndrome, malignancy, or cervical spondylosis with radiculopathy. 3. Obesity (body mass index [BMI] > 30). 4. History of steroid injection into the wrist joint or prior surgical treatment for carpal tunnel syndrome. 5. Current use of vitamin D supplementation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional outcome 2 weeks ,6 weeks, 3 months Thai version Boston Carpal Tunnel Questionnaire,Pain severity 2 weeks ,6 weeks, 3 months Verbal Numerical Rating Scale,Grip strength and Pinch strength 2 weeks ,6 weeks, 3 months grip strength/pinch strength | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrophysiological findings and Pain severity 2 weeks ,6 weeks, 3 months Nerve conduction study | — |
Countries
Thailand
Contacts
Public ContactSitthiphong Suwannaphisit
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Outcome results
None listed