The efficacy and safety of 675 nm laser in the treatment of hypertrophic scar: a quasi experimental pre-post study

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20251001002

Enrollment

Registered

2025-10-01

Start date

2025-01-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

male or female patients aged more than 18 years with more than 3 cm hypertrophic scar Hypertrophic scar, 675 nm laser, Antera, VancouverScar Scale, Collagen

Interventions

Treatment with 675 nm wavelength laser RedTouch will be performed using fluence of 8 Watts, dwelling time of 200 milliseconds, density of 1000 dots per cm2, and 50 percent overlapping area. Each sessi

Experimental Device

675 nm wavelength laser

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Male or female patients aged 18-65 years 2. at least one hypertrophic scar sized more than 3 cm 3. Consent to participate in the program voluntarily and provide written evidence in the informed consent form. 4. Ability to follow research protocols

Exclusion criteria

Exclusion criteria: 1. Female participants who are planning pregnancy, currently pregnant, or breastfeeding. 2. Participants who have received other treatments for hypertrophic scars within the past 4 weeks. 3. Participants who have taken, applied, or been injected with immunosuppressive agents within the past 4 weeks prior to enrollment. 4. Participants with rashes, lesions, infections, or tattoos at the scar site.

Design outcomes

Primary

Measure	Time frame
Volumetric change of hypertrophic scar 4 weeks post-treatment Antera 3D camera	—

Secondary

Measure	Time frame
Severity of hypertrophic scar 12 weeks post-treatment Vancouver Scar Scale,Erythema index 4 and 12 weeks post-treatment Antera 3D camera,Collagen fiber arrangement baseline and 12 weeks post-treatment Histology based with Hematoxylin and Eosin and Masson's Trichrome stain,Pain Score immediate post-operation every 4 weeks and at 4 and 12 weeks post-treatment Verbal Numerical Rating Scale,Adverse event immediate post-operation every 4 weeks and at 4 and 12 weeks post-treatment Incidence of adverse event,Satisfaction level 4 and 12 weeks post-treatment Patient and Observer Scar Scale	—

Measure

Time frame

Severity of hypertrophic scar 12 weeks post-treatment Vancouver Scar Scale,Erythema index 4 and 12 weeks post-treatment Antera 3D camera,Collagen fiber arrangement baseline and 12 weeks post-treatment Histology based with Hematoxylin and Eosin and Masson's Trichrome stain,Pain Score immediate post-operation every 4 weeks and at 4 and 12 weeks post-treatment Verbal Numerical Rating Scale,Adverse event immediate post-operation every 4 weeks and at 4 and 12 weeks post-treatment Incidence of adverse event,Satisfaction level 4 and 12 weeks post-treatment Patient and Observer Scar Scale

—

Countries

Thailand

Contacts

Public ContactNatcha Chottawornsak

Faculty of Medicine, Chulalongkorn university

natchaaa.c@gmail.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026