Elderly participants diagnosed with major depressive disorder. Major depressive disorder Vitamin D Elderly population Epigenetics Biomarkers DNA methylation
Conditions
Interventions
1. Participants who score above 13 on Thai Geriatric Depression Scale (TGDS-30).
2. Participants who diagnosed with a current major depressive disorder by the Mini International Neuropsychiatric Inter
Basic Science,Basic Science
Major depressive disorder,Control
Sponsors
Health Systems Research Institute (HSRI)
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Thai elderly participants who are aged 60 years old or older. (2) Persons who do not supplement with vitamins D. (3) Participants who consent to participate in the research study.
Exclusion criteria
Exclusion criteria: (1) Individuals with communication difficulties. (2) Persons in the terminal stage of life with a life expectancy of less than 6 months. (3) Elderly individuals with uncontrolled chronic diseases, such as those with respiratory or circulatory failure. (4) Persons with physical impairments, such as amputations or deformities of the legs and feet, including paralysis and weakness. (5) Persons who have received blood transfusions, had acute infections, or vaccinations within the last month. (6) Persons with chronic infections and those on immunosuppressive or immunostimulatory drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epigenome profile At the end of the last recruitment. Infinium MethylationEPIC array, epigenetic-wide analysis (EWAS), bioinformatics analysis,Blood parameters At the end of the last recruitment. Chemiluminescence, electrical resistance, hydrodynamic focusing, SLS-haemoglobin, and high-performance liquid chromatography methods | — |
Secondary
| Measure | Time frame |
|---|---|
| Epigenome biomarkers At the end of the last recruitment. Epigenetic-wide and bioinformatics analysis,Mild cognitive impairment At the end of the last recruitment. the Montreal Cognitive Assessment-Thai version (MoCA-Thai) and Thai Mental State Examination (TMSE),Activity of Daily Living and Instrumental Activity of Daily Living performances At the end of the last recruitment. Barthel Index Activity of Daily Living and Lawton Instrumental Activities of Daily Living Scale,Frailty assessment At the end of the last recruitment. Fried phenotype and Kihon Checklist,Physical characteristics At the end of the last recruitment. Chair stand, functional reach, gait speed in 4 meters, hand grip strength, and sit and reach tests | — |
Countries
Thailand
Contacts
Public ContactChanachai Sae Lee
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed