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Use of Topical Ice for Pain Modulation during Intravitreal Injections and Pain Assessment from A Randomized Control Trial

Use of Topical Ice for Pain Modulation during Intravitreal Injections and Pain Assessment from A Randomized Control Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250929006
Enrollment
72
Registered
2025-09-29
Start date
2025-10-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Use of Topical Ice for Pain Modulation during Intravitreal Injections and Pain Assessment in patient with Age related macular degeneration Diabetic retinopathy Retinal vein occlusion Pain Topical ice anesthesia Intravitreal injection

Interventions

Before entering the treatment room participants in intervention group will be given the minus 10degree Celsius ice pack which made of 20ml of water covered in small sterile small glove. And they will
Experimental Procedure/Surgery,No Intervention No treatment
Topical ice placing before intravitreal injection,standard pain control

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age 20 years and above 2. Patients who were diagnosed with DME, DR, AMD or RVO by vitreoretinal specialist. 3. Patients who were diagnosed by OCT 4. Patients who need for intravitreal injections of anti-VEGF as their treatment 5. History of minimum of three IVT injection. 6. For patients who require bilateral IVT injections in the same visit, the eye with the most severe condition will be selected for this study. 7. Willing and signing the written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with conjunctival, episcleral or scleral defects on the study date. 2. Currently received other eyedrop apart from artificial tear in the study eye. 3. History of intraocular surgery in the study eye. 4. Higher than 22 mmHg of Intraocular pressure (IOP) 5. Not willing to attend in this study and denying to give an informed consent.

Design outcomes

Primary

MeasureTime frame
pain score immediately after IVT injection Visual Analog Scale

Secondary

MeasureTime frame
complications after injection 30 minutes after injection observation and slit lamp examination

Countries

Thailand

Contacts

Public ContactChatsiri Phumvichitr

Department of ophthalmology Faculty of Medicine Chulalongkorn University

chatsiri.fernny@gmail.com0877953535

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026