Change in thrombomodulin, vWF Ag and CBA in patients who underwent classical Glenn and pulsatile Glenn operation that completed Fontan operation. Pulsatile Glenn, Antegrade pulmonary blood flow, thrombomodulin, endothelial dysfunction, Von Willebrand factor
Conditions
Interventions
Patients who underwent pulsatile Glenn operation and complete Fontan operation,Patients who underwent classical Glenn operation and complete Fontan operation
Other,Other
Sponsors
Siriraj hospital
Eligibility
Sex/Gender
All
Age
1 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. All consecutive post-Fontan patients age 1 to 60 years old who previously underwent pulsatile bidirectional cavopulmonary connection at Siriraj hospital and aged match post-Fontan patients who did not.
Exclusion criteria
Exclusion criteria: 1. Patients who were not undergone true bidirectional cavopulmonary connection such as Kawashima operation and one-and-a-half operation. 2. Patients whose laboratory data related with endothelial dysfunction and 4D-flow CMR were incomplete. 3. Patients who are known to have disease that associated with abnormal bleeding tendency or thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial dysfunction post-Fontan operation thrombomodulin, vWF: Ag, vWF: CBA | — |
Secondary
| Measure | Time frame |
|---|---|
| Flow mechanics on 4D flow CMR post-Fontan operation Cardiac MRI parameters | — |
Countries
Thailand
Contacts
Public ContactChodchanok Vijarnsorn
Faculty of Medicine Siriraj Hospital
Outcome results
None listed