Age-related cognitive decline and reduced hippocampal volume in older adults. Brain-Derived Neurotrophic Factor, Polymorphism, Exergames, Magnetic Resonance Imaging, Stroop, Brain
Conditions
Interventions
The exergames exercise approach utilised in this investigation was derived from the training protocol outlined by Sato et al. (2021). The participants engaged in a 30-minute physical exercise using th
s instructions during its first usage. Additional enhancements were added in response to game recommendations and demands from participants. During Weeks 1 to 6, the participants engaged in Fitness Mo
s movements by running or crouching. During the battle, the objective was to defeat the enemy and complete the stage by engaging in aerobics, rigorous resistance training, and yoga movements that exer
Experimental Behavioral,Active Comparator Behavioral
Exergames,Conventional
Sponsors
MINISTRY OF HIGHER EDUCATION MALAYSIA
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Only individuals with an MMSE score of 26 or lower, who had either MCI or Alzheimer's Disease. 2. Age between 50-80 years. 3. If the participant receives anti-dementia or mood stabilizing medication, the dose should be stable for at least 3 months before the pre-assessment.
Exclusion criteria
Exclusion criteria: 1. Have co-morbidity that prevents them to exercise and have severe psychiatric disease. 2. Mixed or unclear ethnicity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hippocampus volume Pre-test: Before the start of the 8-week exercise program fMRI during Stroop Task Hippocampal volumetry and Post-test: After completion of the 8-week exercise program Functional Magnetic Resonance Imaging (fMRI) during the Stroop Task (congruent and incongruent trials) to measure executive function and inhibition. | — |
Secondary
| Measure | Time frame |
|---|---|
| fMRI brain activation in the region of interest. Pre-test: Before the start of the 8-week exercise program fMRI during Stroop Task Hippocampal volumetry and Post-test: After completion of the 8-week exercise program Structural MRI (T1-weighted 3D SPGR sequence) with manual tracing in Osirix v12.0 for volumetric analysis | — |
Countries
Malaysia
Contacts
Public ContactHazwani Ahmad Yusof
UNIVERSITI SAINS MALAYSIA
Outcome results
None listed