Efficacy and safety of endovenous microwave ablation versus radiofrequency ablation (EVMA) for great saphenous vein insufficiency : A multicentre, randomized controlled non-inferiority trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250921002

Enrollment

204

Registered

2025-09-21

Start date

2025-06-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with primary chronic venous insufficiency with documented saphenofemoral junction reflux for more than 0.5 seconds on duplex ultrasound. chronic venous disease, endothermal ablation, endovenous microwave ablation, endovenous radiofrequecy ablation

Interventions

Participants in the microwave ablation group will undergo endovenous microwave ablation (EVMA) for treatment of primary varicose veins. The procedure targets the great saphenous vein with documented r

Experimental Device,Experimental Device

EVMA,EVRFA

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: CEAP classification 2 to 6 with primary venous reflux Age more than 18 years Informed consent obtained

Exclusion criteria

Exclusion criteria: Prior venous surgery History or suspicion of deep vein thrombosis Refusal of treatment Pregnancy, breastfeeding, or planning pregnancy

Design outcomes

Primary

Measure	Time frame
GSV occlusion 1,6,12 months yes/no	—

Secondary

Measure	Time frame
Complication 1,6,12 months yes/no,VCSS 1,6,12 months number,CIVIQ 1,6,12 months number,AVVQ 1,6,12 months number	—

Countries

Thailand

Contacts

Public ContactNawaphan Taengsakul

chulabhorn royal acedemy

nawaphan.tan@cra.ac.th0839315588

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026