Efficacy of methoxyflurane on Tourniquet pain and intra-operative pain relief in endoscopic carpal tunnel release: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250920004

Enrollment

Registered

2025-09-20

Start date

2025-09-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carpal tunnel syndrome tourniquet-related pain methoxyflurane carpal tunnel syndrome endoscopic carpal tunnel release tourniquet-related pain tourniquet pain

Interventions

All patients will receive standard endoscopic carpal tunnel release under local anesthesia. Methoxyflurane was applied before the tourniquet was used, and then the surgery was performed. Methoxyfluran

Experimental Drug,Active Comparator Drug

methoxyflurane,local anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years old 2. Diagnosed with carpal tunnel syndrome using criteria of 2/2 1. Pain or numbness at thumb index middle and radial half of ring finger 2 a positive physical examination of Tinel's sign or Phalen test, or Durkan test 3. Electrodiagnostic confirmed with moderate to severe carpal tunnel syndrome according to American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) guideline 4. Persist symptoms at least 3 months after conservative treatment and requiring endoscopic carpal tunnel release

Exclusion criteria

Exclusion criteria: 1. Recurrent carpal tunnel syndrome 2. History of Peripheral neuropathy, Cervical spondylosis radiculopathy 3. Previous fracture/injury or surgery on the affected hand 4. Pregnancy or breastfeeding 5. Meet any contraindication for using methoxyflurane 6. Cognitive impairment

Design outcomes

Primary

Measure	Time frame
tourniquet pain 1 hour Numerical Rating Scales (NRS score) ; pain 0-10	—

Secondary

Measure	Time frame
surgical site pain 1 hour Numerical Rating Scales (NRS score) ; pain 0-10,operative time 1 hour operative time (minute),time-spent in Operating room 1 hour The time counted from when the patient arrives in the operating room until leaving the Operating room (minute),Post-operative numbness 1-week, 3-month complete resolution, incomplete resolution, no improvement (compare to pre-operative status),adverse event during the surgery 1 hour adverse event from methoxyflurane usage, Any problems that lead to converting endoscopic carpal tunnel release to open carpal tunnel release,Postoperative complication 1-hour, 1-week, and 3-month Ecchymosis, Surgical site infection, Pillar pain, Wound dehiscence, Allergic reaction, Reoperation ,Patient satisfaction 1-hour, 1-week, and 3-month 5-point Likert scale (1-5)	—

Measure

Time frame

surgical site pain 1 hour Numerical Rating Scales (NRS score) ; pain 0-10,operative time 1 hour operative time (minute),time-spent in Operating room 1 hour The time counted from when the patient arrives in the operating room until leaving the Operating room (minute),Post-operative numbness 1-week, 3-month complete resolution, incomplete resolution, no improvement (compare to pre-operative status),adverse event during the surgery 1 hour adverse event from methoxyflurane usage, Any problems that lead to converting endoscopic carpal tunnel release to open carpal tunnel release,Postoperative complication 1-hour, 1-week, and 3-month Ecchymosis, Surgical site infection, Pillar pain, Wound dehiscence, Allergic reaction, Reoperation ,Patient satisfaction 1-hour, 1-week, and 3-month 5-point Likert scale (1-5)

—

Countries

Thailand

Contacts

Public ContactPanai Laohaprasitiporn

Faculty of medicine, Siriraj hospital, Mahidol university

panai.lao@mahidol.ac.th024197965

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026