Primary: Compare efficacy of Carvedilol vs. Endoscopic Band Ligation (EBL) in preventing esophageal variceal bleeding in liver cancer patients over 6 months Secondary: Compare survival, liver failure, non-variceal UGIB, and adverse events between Carvedilol and EBL groups. Esophageal band ligation Cirrhosis Carvedilol Hepatocellular carcinoma
Conditions
Interventions
EBL is performed by gastroenterologists using Six-shooter Multi-band Ligator for patients with medium to large esophageal varices. Procedures are repeated every 4 weeks until variceal eradication. Che
Endoscopic band ligation,Carvedilol
Sponsors
Department of Gastroenterology and Hepatology, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 18 years or older 2.Hepatocellular carcinoma, BCLC stage 0 to D 3.Medium to large esophageal varices 4.Patients with cirrhosis of any Child-Pugh class
Exclusion criteria
Exclusion criteria: 1.History of esophageal variceal bleeding (portal hypertensive gastropathy or ectopic varices not excluded) 2.Previous treatment of esophageal varices 3.Use of non-selective beta blockers within 2 weeks 4.Contraindications to non-selective beta blockers 5.Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esophageal varice bleeding 6 month Event bleeding | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Objectives: Compare survival, non-variceal upper GI bleeding, liver decompensation, and treatment-related adverse events between Carvedilol and EBL groups 6 month number of events | — |
Countries
Thailand
Contacts
Public ContactThanatarn Sathidatekoonchorn
Chulalongkorn university
Outcome results
None listed