Abdominal hysterectomy General anesthesia Postoperative pain mirogabalin gabapentin hysterectomy post operative pain
Conditions
Interventions
Oral mirogabalin 10 mg two hours preoperatively followed by every 12 hours for three days,Oral gabapentin 300 mg two hours preoperatively followed by every 12 hours for three days
Active Comparator Drug,Active Comparator Drug
Mirogabalin,Gabapentin
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Scheduled for elective abdominal hysterectomy 2. American Society of Anesthesia (ASA) physical status l and II 3. BMI between 18.5 and 30.0 kg/m2 (normal weight) 4. Patient who can be capable of using intravenous patient-controlled analgesia (IV-PCA)
Exclusion criteria
Exclusion criteria: 1. Patient refuse to participate in the study 2. Patients with known allergies to gabapentiniods 3. Recent use of opioid drugs, NSAIDs, antidepressants or anticonvulsants within 48 hours before surgery 4. Underlying renal impairment (creatinine clearance<60), Hepatic impairment (AST or ALT > 120), Liver cirrhosis child-Pugh class B or C 5. Chronic opioid used 6. Pregnancy or Breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| morphine consumption at 48 hours after surgery dose in mg | — |
Secondary
| Measure | Time frame |
|---|---|
| pain intensity in recovery room every 15 minutes until discharge from recovery room patient reported outcome using a numeric rating scale,pain intensity at ward at 6, 12, 24, 48 hours after surgery patient reported outcome using a numeric rating scale,adverse effects of study drugs after surgery until 48 hours events of postoperative respiratory depression, sedation, pruritus, dizziness, nausea, vomiting | — |
Countries
Thailand
Contacts
Public ContactPassakorn Sawaddiruk
Chiang Mai University
Outcome results
None listed