Efficacy of Combined Intravenous Acetaminophen and Ibuprofen on Early Postoperative Ambulation After Cesarean Delivery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250911005

Enrollment

Registered

2025-09-11

Start date

2025-09-09

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early postoperative ambulation after cesarean delivery between the use of combined intravenous acetaminophen and ibuprofen versus the placebo group Cesarean Delivery, Intravenous Acetaminophen and Ibuprofen, Early Postoperative Ambulation, Breastfeeding

Interventions

Combined Intravenous Acetaminophen and Ibuprofen 300 mg in 100 ml solution for intravenous infusion within 15 minutes after anterior rectus sheath closure,Normal saline 100 ml intravenous infusion wit

Experimental Drug,Placebo Comparator No treatment

Combined intravenous Acetaminophen and Ibuprofen,Normal saline

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Singleton pregnancy GA greater than or equal to 37 weeks, underwent non-emergency cesarean delivery under spinal block with morphine 2. No history of previous cesarean delivery or no more than once previous low transverse cesarean section with Pfannenstiel incision 3. Understand Thai and can follow instructions

Exclusion criteria

Exclusion criteria: 1. GA < 37 weeks 2. Allergy or hypersensitivity to Acetaminophen, NSAIDs, Opioids 3. Patients with active gastrointestinal bleeding, peptic ulceration, cerebrovascular/ cardiovascular disease or other active bleeding 4. Severe hepatic or renal impairment 5. History of smoking, alcohol drinking, or substance use 6. Placenta previa or placenta accreta spectrum 7. Gestational hypertension, preeclampsia with or without severe features 8. Postpartum hemorrhage or postoperative blood transfusion 9. CNS disorder or musculoskeletal disease 10. Intraoperative GI/GU injury 11. Cesarean hysterectomy 12. Postoperative ICU admission 13. Fetal distress or NICU admission 14. Contraindication for breastfeeding e.g. HIV infection, Active HSV/Varicella lesion at breast, Active or untreated tuberculosis, substance use, or chemotherapy

Design outcomes

Primary

Measure	Time frame
Time to ambulation at 6 hours after spinal block with morphine minutes	—

Secondary

Measure	Time frame
Time to initiation of breastfeeding within 72 hours after cesarean delivery minutes,Postoperative pain at 6, 12, 18, 24-hour postoperative Visual analog score,Postoperative opioids use 24-hour postoperative milligrams	—

Countries

Thailand

Contacts

Public ContactSirinya Phanit

Rajavithi hospital

psirinyabz@gmail.com022062900

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026