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Effectiveness of liquid toothpaste containing Coenzyme Q10 in reducing dental plaque and gingivitis

Effectiveness of liquid toothpaste containing Coenzyme Q10 in reducing dental plaque and gingivitis

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250910009
Enrollment
30
Registered
2025-09-10
Start date
2022-05-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal parameters (bleeding on probing, gingival index, plaque index) in healthy participants Gingivitis, gingival inflammation

Interventions

A liquid toothpaste containing Coenzyme Q10 as the primary active ingredient, along with xylitol, peppermint oil, menthol, clove oil, camphor, O-Cymen-5-ol, and sodium benzoate,A cream toothpaste cont
Experimental Device,Experimental Device
Liquid toothpaste,Cream toothpaste

Sponsors

Faculty of Dentistry, Srinakharinwirot University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 24 Years

Inclusion criteria

Inclusion criteria: 1. Having at least 20 natural teeth excluding third molars 2. Not undergoing periodontal treatment or taken antibiotics/antiseptic mouthrinses in the past three months 3. Providing written informed consent

Exclusion criteria

Exclusion criteria: 1. Wearing orthodontic appliances 2. Smoking 3. Having systemic diseases affecting periodontal health 4. Using of corticosteroids or anti-inflammatory drugs during the study period

Design outcomes

Primary

MeasureTime frame
Bleeding on probing Day 0, 7, 21, 28 Periodontal probing,Gingival index Day 0, 7, 21, 28 Score 0-3 by visualization according to Loe & Silness index (1963),Plaque index Day 0, 7, 21, 28 Percent of surface with plaque stained by erythrosine dye according to OLeary et al. (1972)

Secondary

MeasureTime frame
Eight-item questionnaire assessing satisfaction with the toothpaste used Day 7, 28 5-point Likert scale covering cleaning efficacy, brushing motivation, plaque removal, gingival health improvement, absence of irritation, ease of use, scent pleasantness, and purchase intention

Countries

Thailand

Contacts

Public ContactPrima Buranasin

Srinakharinwirot University

prima@g.swu.ac.th026495000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026