The Effect of Centella asiatica Extracts Mouthwash on Oral Wound Healing Following Mandibular Third Molar Surgery: Randomized Controlled Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250909004

Enrollment

Registered

2025-09-09

Start date

2025-09-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A patient with an unerupted impacted mandibular third molar Centella asiatica Mouthwashes Wound Healing Mandibular Third Molar Randomized Controlled Trial

Interventions

Participants will be provided with a 0.12% Centella asiatica mouthwash. They will begin using the mouthwash one day following surgery. The protocol involves rinsing with 15 ml of the solution, retaini

Experimental Drug,Placebo Comparator Drug

0.12% Centella asiatica mouthwash,Plain mouthwash

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18-35 years, regardless of gender. 2. Patients in good health (ASA Class I or II). 3. Patients with at least one impacted third mandibular molar requiring bone removal and tooth sectioning. 4. Patients who can record study outcomes and attend follow-up appointments.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of allergies to medications or Centella asiatica extracts used in the study. 2. Pregnant or breastfeeding patients. 3. Patients with underlying diseases or systemic conditions. 4. Patients experiencing pain from the third mandibular molar or the oral and facial region. 5. Patients who have taken painkillers within one week before surgery. 6. Patients who regularly take dietary supplements or herbal remedies. 7. Patients with infections or pathological conditions related to the third mandibular molar. 8. Patients requiring simultaneous extraction of both third mandibular molars.

Design outcomes

Primary

Measure	Time frame
Oral wound healing index 7 days after surgery Oral Wound Healing Index (clinical scoring method)	—

Secondary

Measure	Time frame
basic fibroblast growth factor (bFGF) day 0 and day 7 Milliplex assay,Facial swelling Day 0 and day 7 digital vernier caliper (mm), Angle of mandible to tragus , external corner of eye, nasal border, labial commissure, soft pogonion,Post-operative pain Post-operative 6-hour, day 1, 2,3,4 and 5 Visual analog scale (VAS)	—

Countries

Thailand

Contacts

Public ContactKathawut Tachasuttirut

Faculty of Dentistry, Chiang Mai University

kathawut.t@cmu.ac.th053944456

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026