Herpes zoster Herpes zoster
Conditions
Interventions
30 participants will be randomly assigned to receive wet compression for wound care by placing sterile gauze soaked with normal saline solution on the vesicles or bullae area and leave for 10-15 minut
Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
Wet compression,Vaseline petroleum jelly,Topical Fucidin ointment (2% fusidic acid ointment)
Sponsors
Faculty of Medicine Siriraj hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients receiving treatment at the Dermatology Department, Outpatient Building, Infectious Skin Disease Clinic, Siriraj Hospital. 2. Clinically diagnosed with cutaneous herpes zoster infection, supported by laboratory confirmation via Tzancks test. 3. Onset of rash within 1 week prior to presentation. 4. Prescribed oral antiviral therapy with acyclovir. 5. Age at least 18 years old 6. No history of allergy to topical antibiotics or to acyclovir or related drugs. 7. Willing to participate in the study voluntarily and to receive treatment according to the study protocol.
Exclusion criteria
Exclusion criteria: 1. Patients with herpes zoster who present with complications, including disseminated herpes zoster, involvement of more than three dermatomes, or secondary bacterial skin infection at the time of examination. 2. Patients with renal disease, defined as a creatinine clearance (calculated by the Cockcroft Gault equation) of less than 30 ml/min 3. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing rate baseline, every 1 week until last scab fall off, 1 month after last scab fall off assessed by dermatologist | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient improvement scale baseline, every 1 week until last scab fall off, 1 month after last scab fall off Quartile scale,Itchiness baseline, every 1 week until last scab fall off, 1 month after last scab fall off Visual analog scale ,Pain score baseline, every 1 week until last scab fall off, 1 month after last scab fall off Visual analog scale,Comfort of using the topical agent baseline, every 1 week until last scab fall off, 1 month after last scab fall off Patient report,Safety baseline, every 1 week until last scab fall off, 1 month after last scab fall off adverse event | — |
Countries
Thailand
Contacts
Public ContactPattriya Jirawattanadon
Faculty of medicine Siriraj hospital, Mahidol university
Outcome results
None listed