Healthy human volunteers with mandibular third molars who plan to have surgery at the Oral and Maxillofacial Surgery Clinic, Faculty of Dentistry, Chiang Mai University Magnesium Postoperative pain Third molar surgery Alternative analgesic
Conditions
Interventions
For the magnesium arm, the study drug is a co-administration of magnesium 500 mg/tablet, which has been manufactured by LifeExtension, Thailand, and paracetamol, approximately 15 mg/kg/dose. The parti
Experimental Drug,Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
Magnesium and Paracetamol,Ibuprofen,Paracetamol,Tramadol-Paracetamol combination
Sponsors
Faculty of Dentistry, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-60 years required surgical removal of the mandibular third molar. 2. ASA (American Society of Anesthesiologists) I or II. 3. Willingness to participate and provide informed consent. 4. Surgery required an ostectomy and/or an odontectomy.
Exclusion criteria
Exclusion criteria: 1. Presented history of allergy to medications used in this study. 2. Pregnancy or breastfeeding. 3. Presented history of systemic disease or conditions contraindicated for magnesium as follows: 3.1. Patients with renal impairment (creatinine clearance of less than 30 mL/min). Since magnesium is cleared renally, patients with renal insufficiency may have an increased risk of heart block or hypermagnesemia. 3.2. Patients taking urinary excretion-reducing drugs, such as calcitonin, glucagon, and potassium-sparing diuretics, may increase serum magnesium levels. 3.3. Patients taking fluoroquinolones, aminoglycosides, bisphosphonates, calcium channel blockers, tetracyclines, and skeletal muscle relaxants. The absorption rate of these drugs may be influenced by the intake of magnesium. 3.4. Patients with a type of muscle weakness called myasthenia gravis. 4. Presented with ongoing orofacial pain on the day of surgery. 5. Presented history of medication or supplement intake that can affect the body's magnesium level. 6. Presented history of analgesic intake within 1 week prior to surgery. 7. Presented psychiatric disorders including depression, anxiety disorders, and psychotic disorders. 8. Presented signs and symptoms of third molar-associated local and/or systemic infection or pathology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Pain intensity at rest and movement at 6 hours , 24 hours, 48 hours, 72 hours, 96 hours, 120 hours after operation Numerical Rating Score | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of rescue analgesic used 7 days after surgery Number of times rescue analgesic used,Health-related quality of life at 6 hours , 24 hours, 48 hours, 72 hours, 96 hours, 120 hours after operation modified questionnaire (severity score) from the Thai version of Oral Impacts on Daily Performance (OIDP),Adverse events 7 days after surgery Patient reported outcome using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactWarit Powcharoen
Faculty of Dentistry, Chiang Mai University
Outcome results
None listed