Male or female with mild to moderate acne aged more or equal to 18 years old. acne, benzoyl peroxide, topical treatment, dapsone, side effects
Conditions
Interventions
Topical 5% dapsone apply on face twice daily.,Control arm was 2.5% benzoyl peroxide apply on face twice daily.
Experimental Drug,Active Comparator Drug
Topical 5% dapsone,2.5% benzoyl peroxide
Sponsors
Faculty of Medicine, Srinakarinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Healthy men and women 2. Age 18 years old and older 3. Mild to moderate acne according to Thai Clinical Practice Guideline for Acne
Exclusion criteria
Exclusion criteria: 1. Use of topical anti-inflammation or topical acne treatment in 4 weeks prior to study 2. Use of oral anti-inflammatory drugs or drugs that may effects acne 4 weeks prior to study 3. Use of oral retinoid within 3 months prior to the study 4. History of Dapsone and Sulfa drugs allergy 5. Pregnant or breastfeeding women 6. Use of high risk drug induced methemoglobinemia ex. sulfasalazine 7. Has dermatitis of other infections than acne at face 8. G6PD deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory lesions reduction baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks number of acne lesions | — |
Secondary
| Measure | Time frame |
|---|---|
| noninflammatory lesions reduction baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks number of acne lesions,total lesion count baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks number of acne lesions,GAAS score baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks GAAS success rate,Side effects 2 weeks, 4 weeks, 6 weeks, 8 weeks, 12 weeks number of occurance,patient satisfaction score 12 weeks visual analog scale | — |
Countries
Thailand
Contacts
Public ContactPinthisa Nisagornsen
Srinakharinwirot University
Outcome results
None listed