abnormal semen analysis curcuminoids, abnormal semen analysis, sperm dna fragmentation, reactive oxygen species
Conditions
Interventions
Curcuminoids 250 mg taken orally twice a day for 3 months.,placebo taken orally twice a day for 3 months.
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Sponsors
Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
Male
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Males aged 20 to 45 years with abnormal semen analysis 2. abstinence period of more than 2 days but not exceeding 7 days
Exclusion criteria
Exclusion criteria: 1. Volunteers with sexually transmitted infections 2. Volunteers with a history of chemotherapy or radiotherapy 3. Volunteers with underlying diseases affecting liver function, kidney function, or blood coagulation 4. Volunteers diagnosed with biliary obstruction 5. Volunteers with abnormal liver or kidney function test results 6. Volunteers diagnosed with infertility due to specific causes, such as hormonal abnormalities, obstruction or congenital absence of the vas deferens, varicocele, or chromosomal abnormalities 7. Volunteers currently using testosterone or other male sex hormone therapies 8. Volunteers currently taking antiplatelet or anticoagulant medications 9. Volunteers who have taken antioxidant supplements within the past 3 months 10. Volunteers who have consumed turmeric extract within the past 3 months 11. Volunteers taking medications that are metabolized by cytochrome P450 enzymes (as curcumin inhibits CYP3A4 and induces CYP2A6)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sperm dna fragmentation 3 months TUNEL assey | — |
Secondary
| Measure | Time frame |
|---|---|
| semen parameter 3 months Computer assisted sperm analysis,reactive oxygen species of spermatozoa 3 months CellROX Staining | — |
Countries
Thailand
Contacts
Public ContactUnyamanee Veeranaraphanit
faculty of medicine, Prince of Songkla University
Outcome results
None listed