Non-Clostridioides difficile infection nosocomial diarrhea in hospitalized adult patients Nosocomial diarrhea Antibiotic-associated diarrhea Probiotics Saccharomyces boulardii Bismuth subsalicylate
Conditions
Interventions
Saccharomyces boulardii (Bioflor) 250 mg capsule orally twice daily for 5 days (500 mg/day).,Bismuth subsalicylate (Gastrobismol-L) 1048 mg tablet orally twice daily for 5 days (2.1 g/day).,Standard c
discretion without adjunctive intervention.
Saccharomyces boulardii,Bismuth subsalicylate,Standard care
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults patients admitted to internal medicine wards or intensive care units. 2. Development of diarrhea during hospitalization defined as at least 3 or more episodes of unformed stools within 24 hours or at least 1 or more episode of mucous bloody stool within 24 hours. 3. Onset of diarrhea occurred after hospital admission for more than 72 hours. 4. Negative stool test for PCR for Clostridioides difficile toxin. 5. No prior history of chronic diarrhea before hospitalization.
Exclusion criteria
Exclusion criteria: 1. Hemodynamic instability. 2. History of bowel resection resulting in short bowel syndrome. 3. Absolute neutrophil count (ANC) less than 1000 cells/mm3. 4. Ongoing chemotherapy session. 5. HIV infection with CD4 count less than 200 cells/mm3. 6. Known allergy or intolerance to probiotics, bismuth or salicylates. 7. Refusal to participate in the study or withdrawal of consent. 8. Patients with nil per os (NPO) status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stool weight At end of intervention (day 5) Weighing stool subtract with its container weight.,Stool frequency At end of intervention (day 5) Number of bowel movements per 24 hours,Stool consistency At end of intervention (day 5) Bristol Stool Form Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Nosocomial diarrhea incidence 12 months Number of hospitalized patients with nosocomial diarrhea,Clinical course of nosocomial diarrhea 7 days Onset of diarrhea, duration of diarrhea, total diarrhea day,Risk factors of nosocomial diarrhea 7 days Patient's factors contributed to diarrhea | — |
Countries
Thailand
Contacts
Public ContactMonthira Maneerattanaporn
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed