Patient aged 18 years old or older undergoing elective spine surgery involving two or more levels dexmedetomidine, non-opioid analgesics, morphine consumption, postoperative pain, adverse drug reactions, intraoperative blood loss, spine surgery, controlled hypotension
Conditions
Interventions
Dexmedetomidine (4 mcg/ml) intravenous infusion 0.5 mcg/kg/hour of ideal body weight,0.9%NaCl intravenous infusion
Active Comparator Drug,Placebo Comparator No treatment
Sponsors
Faculty of medicine, Chulalongkorn university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 years or older 2.Patients undergoing elective spinal surgery involving two or more levels
Exclusion criteria
Exclusion criteria: 1.Patients undergoing emergency spinal surgery 2.Patients who decline to participate in the study 3.Patients with a history of allergy to any drugs used in this study 4.Patients with severe cardiac arrhythmias, including Second-degree AV block, Mobitz type II, Third-degree AV block 5.Pregnant or breastfeeding women 6.Patients unable to use intravenous patient-controlled analgesia 7.Patients with a history of substance abuse or preoperative opioid use 8.Patients with a glomerular filtration rate < 60 mL/min/1.73 square meter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative opioid consumption 24 hrs after surgery Morphine Milligram Equivalents, MME | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score immediately post operation, 1hrs, 3 hrs, 6 hrs, 12 hrs, 24 hrs and 48 hrs after surgery The numeric rating scale (NRS) ,postoperative opioid consumption 1 hrs,3 hrs, 6 hrs, 12 hrs and 48 hrs after surgery Morphine Milligram Equivalents, MME,Time to first opioid administration Time to first opioid administration from arrival in the recovery room minutes ,Time to successful extubation Time to successful extubation, measured from discontinuation of inhalation anesthetics minutes,Incidence and severity of postoperative nausea and vomiting (PONV) immediately post operation, 1hrs, 3 hrs, 6 hrs, 12 hrs, 24 hrs and 48 hrs after surgery PONV impact scale,Patient satisfaction level 24 hrs and 48 hrs after surgery five-point Likert scale,Quality of recovery 48 hrs after surgery 15-item quality of recovery (QoR-15) scale,Incidence of adverse events Intraoperative period to 48 hrs after surgery Times,Intraoperative blood loss intraoperative period milliliter | — |
Countries
Thailand
Contacts
Public ContactPunyaporn Imchai
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed