The effect of intravenous lidocaine combined intravenous dexamethasone on the incidence and severity of postoperative sore throat in patients undergoing laparoscopic gynecological surgery

The effect of intravenous lidocaine combined intravenous dexamethasone on the incidence and severity of postoperative sore throat in patients undergoing laparoscopic gynecological surgery: A Double-blinded Randomized Controlled Trial.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250827021

Enrollment

106

Registered

2025-08-27

Start date

2025-05-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative sore throat in patients undergoing laparoscopic gynecological surgery Postoperative sore throat, cough, hoarseness, laparoscopy, Gynecological surgery

Interventions

Recieve 2%lidocaine preservative free 1.5 mg/kg intravenously at induction phase,Recieve 0.9%NSS as the same volume intravenously at induction phase

Experimental Drug,Placebo Comparator Other

Lidocaine group,Control group

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-65 years 2.The American Society of Anesthesiologists, with physical (ASA) status I or II 3.Scheduled for elective laparoscopic gynecological surgery under general anesthesia 4.Endotracheal intubation

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.BMI > 35 kg/m2 3.High risk of aspiration 4.Heart block or severe cardiac conditions 5.Bradycardia (HR < 60) 6.Smoking 7.Chronic cough or recent upper respiratory tract infection (URTI) 8.Suspected difficult airways 9.Retained ETT from a prior surgery 10.Previous surgery of the oral cavity, neck 11.History of a lidocaine allergy or others anesthetic drugs allergy

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative sore throat 24 hr after extubation sore throat at any time after the operation(sore throat score more than 1)	—

Secondary

Measure	Time frame
Incidence of postoperative sore throat at 30 mins, 1, 6 and 24 hours after extubation sore throat score more than 1,Severity of postoperative sore throat 24 hr after extubation classify into 4 grades,Severity of postoperative cough 24 hr after extubation classify into 4 grades,Severity of postoperative cough 24 hr after extubation classify into 4 grades,Patient satisfaction 24 hr after operation classify into 5 grades	—

Measure

Time frame

Incidence of postoperative sore throat at 30 mins, 1, 6 and 24 hours after extubation sore throat score more than 1,Severity of postoperative sore throat 24 hr after extubation classify into 4 grades,Severity of postoperative cough 24 hr after extubation classify into 4 grades,Severity of postoperative cough 24 hr after extubation classify into 4 grades,Patient satisfaction 24 hr after operation classify into 5 grades

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Countries

Thailand

Contacts

Public ContactSupakan Chaiyabut

Department of Anesthesiology, Faculty of medicine, Khon kaen University

supakan.c@kkumail.com0933236507

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026