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A randomized controlled trial comparing analgesic efficacy of ultrasound-guided serratus anterior plane block (SAPB) versus intravenous morphine in older emergency department patient with rib fractures

A randomized controlled trial comparing analgesic efficacy of ultrasound-guided serratus anterior plane block (SAPB) versus intravenous morphine in older emergency department patient with rib fractures

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250827017
Enrollment
40
Registered
2025-08-27
Start date
2025-09-25
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain management in older adults with trauma is often under-recognized. Rib fractures are a common injury that can cause severe pain and are associated with increased morbidity and mortality if left untreated or inadequately managed. Opioids remain the standard treatment for severe pain

Interventions

Group receiving SAPB The researcher prepared medication for SAPB (stored in the double-lock system drawer in the emergency room). The drug dosage was 1 mg per kilogram body weight of 0.5 percents bupi
Serratus anterior plane block,Morphine intravenous

Sponsors

Navamindradhiraj University Research Fund
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than or equal 65 years old. Presented with Rib fracture. Pain score numeric rating scale more than or equal 5.

Exclusion criteria

Exclusion criteria: Patients need immediate intervention. Patients need acute rescue for STEMI, Stroke, and Aortic dissection. Skin infection at the fracture side. Trauma more than 2 organ. Chronic Kidney Disease stage 5 or eGFR less than 15 ml/mins Take anticoagulants and INR more than 1.7 Cirrhosis child B to C Actual body weight more than 90 kg. History of opioid used within 4 hours. History of alcohol or drug abuse. History of morphine, bupivacaine or fentanyl allergy. Patients with difficulty to communication (e.g. altered mental status, severe dementia (define by 6-items cognitive screening more than 12), language barrier).

Design outcomes

Primary

MeasureTime frame
A reduction of pain score at 30 minutes 30 minutes Verbal numeric rating scale

Secondary

MeasureTime frame
a reduction of pain score 1 hr, 2 hr,4 hr, 6 hr, 12 hr and 24 hr Verbal numeric rating scale ,Adverse events 1 hr, 2 hr, 4 hr, 6 hr , 12 hr, 24 hr Dizziness, Vertigo, hypotension, desaturation,Rescue therapy 30 minutes Give fentanyl 1 microgram per kilogram if the pain does not improve less than 3 ,pulmonary function Initial, 2 hr Spirometry measurement

Countries

Thailand

Contacts

Public ContactJiraporn Srion

Vajira Hospital, Navamindradhiraj University

jirapon@nmu.ac.th0896840010

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026