Septic shock patients receiving low-dose vasopressors Septic shock Methylene blue
Conditions
Interventions
Methylene blue 100 mg in 100 mL of 5% dextrose in water, administered via continuous intravenous infusion over 6 hours per day, until vasopressors could be discontinued for 24 hours, with a total trea
Active Comparator Drug,Placebo Comparator Drug
Methylene blue,5% dextrose in water
Sponsors
Phramongkutklao hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with septic shock who received high-dose vasopressors prior to study enrollment equivalent to norepinephrine greater than or equal to 0.05 mcg/kg/min
Exclusion criteria
Exclusion criteria: 1. Patients with septic shock who received high-dose vasopressors prior to study enrollment equivalent to norepinephrine greater than or equal to 0.25 mcg/kg/min 2. Patients with concurrent shock of other etiologies, including hemorrhagic shock, obstructive shock, or cardiogenic shock 3. Patients with a history of allergy to methylene blue 4. Patients with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency, a family history of G6PD deficiency, or a G6PD enzyme level of less than 197 IU/100 mL of red blood cells 5. Patients receiving selective serotonin reuptake inhibitors (SSRIs) 6. Pregnant patients 6. Patients with burn injuries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to vasopressor discontinuation Time to vasopressor discontinuation Hours / Continuous hemodynamic monitoring, recorded from time of enrollment until vasopressor discontinuation. | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP at 1, 6, 12, 24, 48, 72 hours at 1, 6, 12, 24, 48, 72 hours after start intervention mmHg / Continuous hemodynamic monitoring,Serum lactate level at 1, 6, 12, 24, 48, 72 hours at 1, 6, 12, 24, 48, 72 hours after start intervention mmol/L / Blood test,Maximum dose of vasopressor at 72 hours after start intervention mcg/kg/min / Medical record,Cumulative norepinephrine dose at 72 hours after start intervention mcg/kg/min / Medical record,Vasopressor-free day at 7 days after start intervention day / Medical record,Hydrocortisone use at 72 hours after start intervention percent / Medical record,Cumulative fluid intake at 72 hours after start intervention mL / Medical record,Incident of refractory shock at 28 days after enrollment percent / Medical record,Incidence of recurrent shock within 7 days at 7 days after start intervention percent / Medical record,Incidence of receiving renal replacement therapy at 72 hours after start intervention percent / Medical record,Ventilator-free days at 7 days after start intervention day / Medical record,Length of stay in the ICU at 28 days after enrollment day / Medical record,Length of stay in the hospital at 28 days after enrollment day / Medical record,Mortality rate at 7, 14, 28 day at 7, 14, 28 day after enrollment day / Medical record | — |
Countries
Thailand
Contacts
Public ContactSasathorn Tharapoom
Division of pulmonary and critical care, Phramongkutklao hospital
Outcome results
None listed