Comparison of the outcomes of implant placement simultaneous with GBR between using Hyaluronate-combined bone substitute and xenograft in the aesthetic area: A Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250827005

Enrollment

Registered

2025-08-27

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who had a requirement and were eligible for surgical implant placement simultaneous with GBR for the replacement in a partially edentulous area in anterior maxilla Dental implant GBR

Interventions

The patient who received surgical implant placement simultaneous with GBR using xenograft combined with sodium hyaluronate and collagen resorbable membrane,The patient who received surgical implant pl

Experimental Other,Active Comparator Other

xenograft with sodium hyaluronate,xenograft

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1 Individuals who age over 20 years. 2 Good general health or well-controlled disease (ASA Class I or II). 3 Individuals who have an edentulous area or the presence of a hopeless tooth that required extraction and replacement in the central, lateral incisor, canine, first or second premolar region of the maxilla suitable for the simultaneous dental implant placement with GBR. 4 If individuals presented with more than one site of implant placement, the split-mouth technique will be applied.

Exclusion criteria

Exclusion criteria: 1 Individuals who have uncontrolled diseases, immunodeficiency, history of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years. 2 Individuals being pregnant or breastfeeding. 3 Individuals who have allergy to any material and/or medication used in the study. 4 Individuals who are unwilling to continue for the follow-up period.

Design outcomes

Primary

Measure	Time frame
The facial bone thickness 6 months The facial bone thickness will be measured in millimeters on the CBCT image perpendicular to the axis of implant at the mid-aspect of implant platform, 2, 4, and 6 mm apical to the implant platform.	—

Secondary

Measure	Time frame
Clinical parameters 6 months Clinical outcomes and complication, including presence of Implant mobility, membrane exposure, flap dehiscence, presence of suppuration	—

Countries

Timor-Leste

Contacts

Public ContactSirida Arunjaroensuk

Faculty of Dentistry, Chulalongkorn University

sirida.a@chula.ac.th022188587

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026