Healthy condition Positive list
Conditions
Interventions
Who consume a capsule containing Lactose and Polyvinylpyrrolidone (PVP-K90) without Mulberry powder.,Who consume a capsule containing Mulberry powder (Low dose), Lactose, and Polyvinylpyrrolidone (PVP
Placebo,MB capsule Low dose,MB capsule high dose
Sponsors
Program Management Unit Competitiveness (PMUC)
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Male and female volunteers aged 35-65 years 2) Body mass index in the range of 18-25 kg/m2 3) Stress assessment results were normal (score less than 7) from the assessment using the Depression, Anxiety and Stress Assessment Scale (DASS-21) 4) Do not regularly consume probiotic foods such as Yakult, sour milk, yogurt 5) Able to communicate, read and write in Thai
Exclusion criteria
Exclusion criteria: 1) Have chronic diseases that require continuous medication, such as cardiovascular disease or blood clot blockage, lung disease, thyroid disease, adrenal gland, pituitary gland, cancer, diabetes, allergies, liver disease. 2) Take cholesterol-lowering drugs, blood sugar-lowering drugs, blood pressure-lowering drugs, or drugs that interfere with platelet function, such as aspirin and nonsteroidal anti-inflammatory drugs before participating in the research project. 3) Take birth control pills or hormones or dietary supplements regularly. 4) Take other dietary supplements. affecting the brain, heart and blood vessels, as well as metabolic processes, such as weight loss and fat reduction before joining the research project 5) Drinking more than 5 alcoholic beverages per day 6) Smoking more than 10 cigarettes per day 7) Being an athlete who exercises regularly (more than 3 times per week) 8) Currently using birth control pills 9) Being pregnant or planning to become pregnant during the research 10) Currently breastfeeding 11) Currently participating in other projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cellular Senescence And Age-Related Disorders 0, 12 week Endothelial vascular ageing , Skin ageing (Hydration, Wrinkle, Elasticity | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety parameters (Physical) 0, 6, 12 week Vital sing, Electrocardiogram, Body Mass Index (BMI), Body Composition ,Safety parameters (Clinical blood analysis) 0, 12 week CBC, Blood Chemistry by hospital laboratory.,Physical fitness 0, 6, 12 week Hand grip strength, 10-M walk test, Time-up and go test, 5-times sit to stand test, Chair sit and reach test,Psychological fitness 0, 6, 12 week DASS-21, The Pittsburgh sleep quality index : PSQI, WHOQOL-BREF,Working memory 0, 6, 12 week Computerized battery test,Skin aging mechanism 0, 12 week Telomerase ELISA kit,Oxidative stress 0, 12 week 8-OHdG, MDA, SOD, CAT, Gpx by HHP&HP Laboratory,Proinflmmatory cytokine 0, 12 week NF-KB, IL-6 ELISA kit,Neurotransmitters 0, 12 week AChE, MAO, GABA-T, GAD by HHP&HP Laboratory,Neuroplasticity 0, 12 week Brain derived growth factor (BDNF) ELISA kit,Lung related inflammation markers 0, 12 week Sirtuin ELISA kit,Whole-genome metabolic modeling, or genome-scale metabolic models 0, 12 week By using Whole Genome Sequencing (WGS) Oxford Nanopore Technologies (ONT) | — |
Countries
Thailand
Contacts
Public ContactJintanaporn Wattanathorn
Faculty of Medicine, Khon Kaen University
Outcome results
None listed