Antioxidant and anti-inflammatory effects of hydrogen inhalation therapy after exposure to PM2.5 in human

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250823007

Enrollment

Registered

2025-08-23

Start date

2026-08-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy healthcare workers Healthy, controls, health care worker

Interventions

1-hour inhalation of 99.99% H2 generated through a nasal cannula

Experimental Procedure/Surgery

Hydrogen Therapy

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Healthy healthcare workers aged 20-60 years 2. No uncontrolled underlying cardiovascular, respiratory, neurological, and metabolic diseases

Exclusion criteria

Exclusion criteria: 1. Smoking status: current smokers or ex-smokers < 6 months 2. BMI > 30 kg/m2 3. Pregnancy or planning to become pregnant during the study period 4. Use air purifiers and/or home air purifier system 5. Regular taking medications, nutritional products or vitamins proved to have antioxidant properties e.g., N-acetylcysteine, vitamin C, vitamin E, and omega-3 fatty acid. 6. Acute infection within prior 4 weeks 7. Heavy exercise 1 week before blood sampling 8. Immunocompromised conditions or treated with long-term systemic steroids or immunosuppressive agents 9. Active cancer at any stages 10. Severe stage of underlying diseases: end-stage renal disease or requiring long- term dialysis, cirrhosis Child-Pugh C, respiratory diseases treated with biologic agents

Design outcomes

Primary

Measure	Time frame
Serum total oxidant status 1. Baseline (August 2025): 2. March 2026: A)Immediately before HIT B)Immediately after HIT C)24 hours after HIT unit	—

Secondary

Measure	Time frame
Fractional exhale nitric oxide (FeNO) 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT part per billion,Spirometry 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT %,Impulse oscillometry (IOS) 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT %	—

Measure

Time frame

Fractional exhale nitric oxide (FeNO) 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT part per billion,Spirometry 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT %,Impulse oscillometry (IOS) 1. Baseline (August 2025): 2. March 2026: A) Immediately before HIT B) Immediately after HIT C) 24 hours after HIT %

—

Countries

Thailand

Contacts

Public ContactWarawut Chaiwong

Chiang Mai University

warawut.chai@cmu.ac.th0848092122

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026