exercise-induced muscle damage. exercise-induced muscle damage, Sahastara Remedy Extract, myalgia, efficacy, Muscle strength.
Conditions
Interventions
Participants will receive nine capsules containing 100 mg of Sahastara remedy extract per capsule. They will be instructed to take one capsule before each meal, three times per day, for three days fol
Experimental Dietary Supplement,Placebo Comparator No treatment
Sahastara remedy extract capsule group,Placebo capsule group
Sponsors
National Science, Research and Innovation Fund
Eligibility
Sex/Gender
Male
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Participant aged 18 and 30 years 2. Body mass index (BMI) between 18.5 and 22.9 Kg/m2 3. Moderate and vigorous physical activity is less than 150 min per week 4. Alcohol consumption is less than 40 grams/day
Exclusion criteria
Exclusion criteria: 1. Level of creatine kinase is more than 190 U/L 2. Level of lactate dehydrogenase is more than 280 U/L 3. Level of C-reactive protein is more than 2 mg/L 4. Smoking behavior 5. Having medical conditions that must take continuously medicine 6. Having musculoskeletal disorder 7. Currently undergoing antihistamines therapy (terfenadine, astemizole, loratadine, cetirizine), bronchodilators (salbutamol), Decongestant (pseudoephedrine, phenylephrine) 8. Abnormal range of CBC -PLT count is less than 125,000 cells/microliter -Hct is more than 40 percentage -Hb is more than 11 g/dL 9. Abnormal liver and renal function testing -AST is more than 2 times of ULN (40 U/L) -ALT is more than 2 times of ULN (40 U/L) -ALP is more than 1.5 times of ULN (140 U/L) -Creatinine is more than 1.5 times of ULN (1.35 mg/dL) -BUN is more than 1.5 times of ULN (20 mg/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle damage marker baseline, 24, 48, and 72 hr. after performing exercise-induced muscle damage Creatine kinase,Muscle damage marker baseline, 24, 48, and 72 hr. after performing exercise-induced muscle damage lactate dehydrogenase,Inflammatory marker baseline, 24, 48, and 72 hr. after performing exercise-induced muscle damage C-reactive protein,Muscle strength baseline, 0, 24, 48, and 72 hr. after performing exercise-induced muscle damage Isokinetic dynamometer,Range of motion baseline, 0, 24, 48, and 72 hr. after performing exercise-induced muscle damage Knee range of motion,Neuromuscular function baseline, 0, 24, 48, and 72 hr. after performing exercise-induced muscle damage Surface electromyography,Muscle circumference baseline, 24, 48, and 72 hr. after performing exercise-induced muscle damage Thigh circumference,Pain score baseline, 0, 24, 48, and 72 hr. after performing exercise-induced muscle damage 100 mm visual analog scale,Muscle power baseline, 0, 24, 48, and 72 hr. after performing exercise-induced muscle damage Isokinetic dynamometer | — |
Secondary
| Measure | Time frame |
|---|---|
| Changing protein pattern in blood sampling baseline, 24, 48, and 72 hr. after performing exercise-induced muscle damage Proteomics | — |
Countries
Thailand
Contacts
Public ContactThanarak Wongwattanapong
The Faculty of Medicine, Thammasat University
Outcome results
None listed