Tuberculosis control focused on the household contacts of newly people diagnosed with Tuberculosis Tuberculosis Preventive Therapy Active-case-finding Tuberculosis Screening Pragmatic Cluster-Randomized Trial Stepped-Wedge design
Conditions
Interventions
Current strategy relying on passive case detection and advice provided to TB patients to refer HH contacts to the TB clinic for screening. The index TB patient will be asked to enumerate HH contacts a
(ii) children 2-12 years: INH and rifapentine weekly for 3 months
(iii) childrenmore or equal than 13 and adults: INH and rifapentine daily for 1 month.
No Intervention Other,Experimental Other
Standard of care,TB Case-Finding, Treatment and Prevention Intervention
Sponsors
French National Research Institute for Sustainable Development (IRD)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion of the INDEX cases Age more or equal than 18 years Newly bacteriologically confirmed TB case (within 1 month of diagnosis) Living in the same household for the last 3 months Reporting at least one HH contact Providing written informed consent for participation in the study Inclusion of CONTACTS All contacts living in the same HH, defined as any person who shared the same enclosed living space as the index TB case for one or more nights or for frequent or extended daytime periods for at least one month before the TB diagnosis is made. Providing written informed consent (signed by adult (more or equal than 18 years) contacts; or by parents/guardians for minors less than 13 years or incapacitated people; written assent for children more or equal than 13 years and less than 18 years).
Exclusion criteria
Exclusion criteria: Exclusion of INDEX cases Index cases who do not live in the catchment area of the study cluster Index cases diagnosed with rifampicin resistance, MDR or XDR-TB Index cases who are incarcerated Exclusion of the CONTACTS Contacts currently on TPT or on TB treatment or who finished such treatment in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tuberculosis preventive treatment coverage Within 2 months from the recruitment of Index cases Number of household contacts initiated on tuberculosis preventive treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| tuberculosis preventive treatment coverage At 1 month for those participants under 1HP regiment, at 3 months for thos participants under 3HP and 3HR regiments Number of household contacts who complete the tuberculosis preventive treatment,TPT safety At 1 month for those participants under 1HP regiment, at 3 months for thos participants under 3HP and 3HR regiments Number of SAE events declared during the study period,Epidemiological impact At 9 months of follow up Number of household contacts initated on TPT who developed tuberculosis | — |
Countries
Thailand
Contacts
Public ContactTamara Tovar Sanchez
IRD
Outcome results
None listed